849035-61-6Relevant academic research and scientific papers
SYNTHESIS OF NOVEL TUBULIN POLYMERIZATION INHIBITORS: BENZOYLPHENYLUREA (BPU) SULFUR ANALOGS
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Page/Page column 20, (2009/04/24)
This invention provides a series of BPU analogues; their synthesis and evaluated biological activity. BPU sulfur analogues were found to possess up to 20 fold increased potency, when compared to compound 1, in various cancerous cell lines.
Benzoylphenylurea sulfur analogues with potent antitumor activity
Hallur, Gurulingappa,Jimeno, Antonio,Dalrymple, Susan,Zhu, Tao,Jung, M. Katherine,Hidalgo, Manuel,Isaacs, John T.,Sukumar, Saraswati,Hamel, Ernest,Khan, Saeed R.
, p. 2357 - 2360 (2007/10/03)
A novel series of BPU analogues were synthesized and evaluated for antitumor activity. In particular, BPU sulfur analogues 6n and 7d were shown to possess up to 10-fold increased potency, when compared to 1 (NSC-639829), against cancer cell lines. 6n was
DESIGN AND SYNTHESIS OF NOVEL TUBULIN POLYMERIZATION INHIBITORS: BONZOYLPHENYLURIA (BPU) SULFUR ANALOGS
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Page/Page column 40, (2008/06/13)
A novel series of BPU analogues were synthesized and evaluated for antitumor activity. In particular, BPU sulfur analogues 6n and 7d were shown to possess up to 10-fold increased potency, when compared to compound 1, against cancer cell lines. 6n was more
