84907-98-2

Usage

Uses

Used in Pharmaceutical Industry:
(R)-2-Amino-succinic acid 4-tert-butyl ester 1-methyl ester is used as a synthetic building block for the development of new pharmaceutical compounds. Its unique structure and reactivity allow for the creation of novel molecules with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, (R)-2-Amino-succinic acid 4-tert-butyl ester 1-methyl ester is used as a key intermediate in the synthesis of various agrochemical products, such as pesticides and fertilizers, due to its stability and versatility in organic chemistry.
Used in Materials Science:
(R)-2-Amino-succinic acid 4-tert-butyl ester 1-methyl ester is utilized as a component in the development of new materials with specific properties, such as improved strength, durability, or chemical resistance, thanks to its unique structural features and reactivity.

Upstream product

• 84907-97-1 ((2R,5S)-5-tert-Butyl-3,6-dimethoxy-2,5-dihydro-pyrazin-2-yl)-acetic acid tert-butyl ester 
• 71989-14-5 Fmoc-(tBu)Asp-OH 
• 17812-32-7 H-Asp-OMe 
• 115-11-7 isobutene 
• 186581-53-3 diazomethane 
• 1334631-58-1 L-aspartic acid β-tert-butyl ester hydrochloride 
• 4668-42-2 (S)-2-benzyloxycarbonylamino-succinic acid 1-methyl ester 
• 5545-52-8 Z-D(tBu)-OH 
• 172846-53-6 4-(tert-butyl) 1-methyl (((9H-fluoren-9-yl)methoxy)carbonyl)-L-aspartate 
• 63327-57-1 (2S), 2-benzyloxycarbonylamino-succinic acid 1-methyl ester 4-tertiobutyl ester 

Downstream Products

• 932725-87-6 4-[O-(5-nitro)furfuryl N-methyl-N-(4-chlorobutyl) phosphono(difluoromethyl)]phenylacetic-(L)-aspartic acid β-tert-butyl ester α-methyl ester 
• 2673-19-0 4-tert-butyl 1-methyl L-aspartate hydrochloride 
• 350697-41-5 N-benzyl-N-(2-hydroxy-ethyl)-2-(4-methoxy-benzenesulfonylamino)-succinamic acid methyl ester 
• 350697-42-6 (R)-4-((S)-2-Hydroxymethyl-pyrrolidin-1-yl)-2-(4-methoxy-benzenesulfonylamino)-4-oxo-butyric acid methyl ester 
• 350697-36-8 N-cyclohexyl-2-(4-methoxy-benzenesulfonylamino)-succinamic acid methyl ester 
• 350697-38-0 N-benzyl-2-(4-methoxy-benzenesulfonylamino)-succinamic acid methyl ester 
• 350697-40-4 N-(2-hydroxy-ethyl)-N-isopropyl-2-(4-methoxy-benzenesulfonylamino)-succinamic acid methyl ester 
• 350697-39-1 2-(4-methoxy-benzenesulfonylamino)-N-(2-methoxy-ethyl)-succinamic acid methyl ester 
• 350697-37-9 N-tert-butyl-2-(4-methoxy-benzenesulfonylamino)-succinamic acid methyl ester 
• 350697-35-7 N-isopropyl-2-(4-methoxy-benzenesulfonylamino)-succinamic acid methyl ester 

Relevant academic research and scientific papers

Kinetic Selection in the Out-of-Equilibrium Autocatalytic Reaction Networks that Produce Macrocyclic Peptides

Autocatalytic reaction networks are instrumental for validating scenarios for the emergence of life on Earth and for synthesizing life de novo. Here, we demonstrate that dimeric thioesters of tripeptides with the general structure (Cys-Xxx-Gly-SEt)2 form strongly interconnected autocatalytic reaction networks that predominantly generate macrocyclic peptides up to 69 amino acids long. Some macrocycles of 6–12 amino acids were isolated from the product pool and were characterized by NMR spectroscopy and single-crystal X-ray analysis. We studied the autocatalytic formation of macrocycles in a flow reactor in the presence of acrylamide, whose conjugate addition to thiols served as a model “removal” reaction. These results indicate that even not template-assisted autocatalytic production combined with competing removal of molecular species in an open compartment could be a feasible route for selecting functional molecules during the pre-Darwinian stages of molecular evolution.

A polypeptide material aspartic acid tert-butyl β - α - methyl ester hydrochloride preparation method

The invention discloses a polypeptide material aspartic acid tert-butyl β - α - methyl ester hydrochloride of the preparation method, is mainly composed of complex technology, cycle is long, the yield is low, the cost is high, the risk is high, does not meet the technical problems of production and the like. Preparation method of this invention comprises the following steps: 1st step, the aspartic acid suspended in dry tetrahydrofuran, in phosphorus oxychloride under the action of the aspartic acid in the preparation into the anhydride hydrochloride; 2nd step, aspartic acid anhydride hydrochloride suspended in methanol reaction to obtain the aspartic acid α - methyl ester hydrochloride, triethylamine for adjusting pH value so that the aspartic acid methyl α - separated out; 3rd step, aspartic acid methyl α - suspended in methylene chloride, access isobutene, concentrated sulfuric, sealed reaction to obtain the oil of aspartic acid tert-butyl methyl α - β -; 4th step, the oil of aspartic acid tert-butyl methyl α - β - dissolved in ethyl ether, dropping ethyl ether - hydrochloric acid gas, the final product is obtained α - β - tert-butyl aspartic acid methyl ester hydrochloride.

Synthesis and anti-HIV-1 activity of new conjugates of 18β- and 18α-glycyrrhizic acids with aspartic acid esters

New conjugates of 18β- and 18α-glycyrrhizic acids (GAs) each containing two di- or α-methyl esters of L-aspartic acid in the carbohydrate part of the glycosides were synthesized by the activated ester method using the N-hydroxysuccinimide (HOSu) and N,N'-dicyclohexylcarbodiimide. It was found that the conjugate of 18β-GA with Asp(OMe)(OMe) (4) at a concentration of 250 μg/mL inhibited effectively RT of HIV-1 and the accumulation of virus antigen p24 in MT-4 cell culture (95-97%) and protected cells from the cytopathogenic action of the virus.

NMR determinations of the absolute configuration of α-chiral primary amines

(Figure presented) We have established a methodology to determine the absolute configuration of α-chiral primary amines by derivatization to the corresponding imines with each enantiomer of 2′-methoxy-1,1′- binaphthalene-8-carbaldehyde (1). This methodology proceeds on the basis of modified Moshers method, and sufficiently large ΔδR S values can be obtained to elucidate the stereochemistry of the amines.

Synthesis and cell-based activity of a potent and selective protein tyrosine phosphatase 1B inhibitor prodrug

Our laboratory recently reported the development of novel prodrug chemistry for the intracellular delivery of phosphotyrosine mimetics. This chemistry has now been adapted for the synthesis of a prodrug that delivers the nonhydrolyzable difluoromethylphos

ENANTIOSELECTIVE SYNTHESIS OF NON-PROTEINOGENIC AMINO ACIDS VIA METALLATED BIS-LACTIM ETHERS OF 2,5-DIKETOPIPERAZINES

Bis-lactim ethers 1 of 2,5-diketopiperazines contain a chiral inducing center, an acidic CH-bond and two sites susceptible to hydrolysis.They react with BuLi to give Li compounds of type 4, 15, 29 or 32, which possess a prochiral C atom.They readily add electrophiles (such as alkylating agents or carbonyl compounds) with unusually high diastereoface differentiation.In many cases the d.e-value (d.e. = diastereomeric excess = asymmetric induction) of the adduct exceeds 95percent.On hydrolysis the adducts are cleaved liberating the chiral auxiliary (used to build up the bis-lactim ether 1) and the target molecules, the optically active amino acid methyl esters of type 8, 19, 25 or 36.The two amino acid esters are separable either by fractional distillation or (eventually after further hydrolysis to amino acids) by chromatography.Transition state models are discussed that could explain the exceptionally high asymmetric induction and the predictability of the induced configuration.