84911-33-1Relevant articles and documents
Synthesis of the Carbapenam System from Glutamic Acid and Acetoacetic Acid Derivatives
Bachi, Mario D.,Breiman, Ron,Meshulam, Haim
, p. 1439 - 1444 (1983)
A synthesis of carbapenam-3-carboxylates is described.Ethyl pyroglutamate was converted into the corresponding thioamide 6 which was subjected to an alkylative sulfide contraction with ethyl 2-bromoacetoacetate.The resulting enamino keto ester 7 was hydro