849110-27-6Relevant academic research and scientific papers
Adenine Derivatives: Promising Candidates for Breast Cancer Treatment
Figueiredo, Pedro,Costa, Marta,Pontes, Olívia,Baltazar, Fátima,Proen?a, Fernanda
, p. 3943 - 3956 (2018)
The cascade reaction of N-aryl-5-{[(dimethylamino)methylene]amino}-4-cyanoimidazoles with primary aromatic amines, under reflux in acetic acid, proved to be a general and efficient method for the regioselective synthesis of 6-arylaminopurines. A selection of these compounds was tested in breast cancer cell models MCF-7 and Hs578t and five compounds proved to be highly active and non-toxic to the non-neoplastic cell line MCF-10A. Furthermore, the compounds demonstrated apoptosis-inducing capacity in the cancer cells.
Synthesis and radical scavenging activity of phenol-imidazole conjugates
Correia, Carla,Leite, Cláudia,Proen?a, M. Fernanda,Carvalho, M. Alice
, p. 2768 - 2772 (2014/06/09)
Novel hydroxylated benzylideneamino imidazole derivatives were synthesized and their radical scavenging activity was assessed against DPPH and hydroxyl radicals. In the DPPH assay, most of the synthesized compounds showed an IC 50 in the range
