849129-97-1Relevant academic research and scientific papers
Synthesis and in vitro antimicrobial activity of benzo[b][1,4]thiazin-3(4H) -ones via smiles rearrangement
Yang, Hao,Fang, Liang,Li, Zhu-Bo,Ren, Fang-Kui,Wang, Li-Ying,Tian, Xiao,Shin, Dong-Soo,Zuo, Hua
experimental part, p. 93 - 100 (2012/02/16)
New benzo[b][1,4]thiazin-3(4H)-one derivatives (compounds 12a-p) were synthesized via Smiles rearrangement and assayed in vitro for their antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. The antimicrobial activity of the benzo[b][1,4]thiazin-3(4H)-ones showed, on the whole, potent toward all tested Gram-positive and Gram-negative microorganism (minimal inhibitory concentration ranging from 16 to 64 lg/ml), whereas weak effectiveness was exhibited against fungi. Data obtained suggested that 12g, 12i, and 12o exerted the best antibacterial activity against Gram-positive bacteria and compound 12b demonstrated the best inhibition of Gram-negative bacteria. These observations provide some predictions to design further antimicrobial active compounds prior to their synthesis following with molecular modeling studies. Springer Science+Business Media, LLC 2010.
