849199-45-7

Basic information

• Product Name: 2(1H)-Pyrazinone, 1-[(4-methoxyphenyl)methyl]-5-phenyl-
• CAS NO: 849199-45-7
• Molecular Formula: C18H16N2O2
• Molecular Weight: 292.337
• Mol File: 849199-45-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2(1H)-Pyrazinone, 1-[(4-methoxyphenyl)methyl]-5-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Pyrazinone, 1-[(4-methoxyphenyl)methyl]-5-phenyl-(849199-45-7)
• EPA Substance Registry System: 2(1H)-Pyrazinone, 1-[(4-methoxyphenyl)methyl]-5-phenyl-(849199-45-7)

Safety Data

• Hazardous Substances Data: 849199-45-7(Hazardous Substances Data)

Upstream product

• 25844-72-8 6-phenyl-3(2H)-pyridazinone 
• 1074-12-0 phenylglyoxal hydrate 
• 824-94-2 p-methoxybenzyl chloride 

Downstream Products

• 849199-59-3 5-phenylimidazo[1,5-a]pyrazin-8(7H)-one 
• 849199-52-6 7-(4-methoxybenzyl)-5-phenylimidazo[1,5-a]pyrazin-8(7H)-one 

Relevant articles and documents

C?H Methylation of Iminoamido Heterocycles with Sulfur Ylides**

The direct methylation of N-heterocycles is an important transformation for the advancement of pharmaceuticals, agrochemicals, functional materials, and other chemical entities. Herein, the unprecedented C(sp2)-H methylation of iminoamido heterocycles as nucleoside base analogues is described. Notably, trimethylsulfoxonium salt was employed as a methylating agent under aqueous conditions. A wide substrate scope and excellent level of functional-group tolerance were attained. Moreover, this method can be readily applied to the site-selective methylation of azauracil nucleosides. The feasibility of gram-scale reactions and various transformations of the products highlight the synthetic potential of the developed method. Combined deuterium-labeling experiments aided the elucidation of a plausible reaction mechanism.