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84921-89-1

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84921-89-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 84921-89-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,4,9,2 and 1 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 84921-89:
(7*8)+(6*4)+(5*9)+(4*2)+(3*1)+(2*8)+(1*9)=161
161 % 10 = 1
So 84921-89-1 is a valid CAS Registry Number.

84921-89-1Relevant articles and documents

Use of 'small but smart' libraries to enhance the enantioselectivity of an esterase from Bacillus stearothermophilus towards tetrahydrofuran-3-yl acetate

Nobili, Alberto,Gall, Markus G.,Pavlidis, Ioannis V.,Thompson, Mark L.,Schmidt, Marlen,Bornscheuer, Uwe T.

, p. 3084 - 3093 (2013)

Two libraries of simultaneous double mutations in the active site region of an esterase from Bacillus stearothermophilus were constructed to improve the enantioselectivity in the hydrolysis of tetrahydrofuran-3-yl acetate. As screening of large mutant libraries is hampered by the necessity for GC/MS analysis, mutant libraries were designed according to a 'small but smart' concept. The design of focused libraries was based on data derived from a structural alignment of 3317 amino acid sequences of α/β-hydrolase fold enzymes with the bioinformatic tool 3dm. In this way, the number of mutants to be screened was substantially reduced as compared with a standard site-saturation mutagenesis approach. Whereas the wild-type esterase showed only poor enantioselectivity (E = 4.3) in the hydrolysis of (S)-tetrahydrofuran-3-yl acetate, the best variants obtained with this approach showed increased E-values of up to 10.4. Furthermore, some variants with inverted enantiopreference were found. A semi-rational approach was applied for the enhancement of the enantioselectivity of an esterase from Bacillus stearothermophilus towards the industrially interesting substrate tetrahydrofuran-3-yl acetate, based on data derived from structural alignment. The design of 'small but smart' libraries led to a 2.4-fold increase of (S)-selectivity compared to wild type enzyme, while some mutants with marginal (R)-selectivity were found.

Preparation method of hydroxyl oxacycloalkane derivative

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Paragraph 0049-0070, (2021/08/14)

The invention relates to a preparation method of a hydroxyl oxacycloalkane derivative, which comprises the following steps: 1) preparing an initial reaction raw material compound and a catalyst into a raw material solution by using a solvent, and respectively pumping the raw material solution and an oxide material into a continuous flow reactor preheating module from different material conveying equipment for preheating; 2) feeding the material passing through the preheating module into a mixing module, feeding the mixed material into a reaction module, and continuously reacting in the reaction module to obtain a reaction mixture; (3) after the reaction, enabling a reaction mixture to enter a product separation module, and carrying out organic-inorganic separation or solvent removal on reaction liquid at cooling or reaction temperature or raised temperature to obtain a crude product; and refining the crude product to obtain a pure product. According to the method disclosed by the invention, the reaction process can be simplified, the reaction time can be shortened, and the hydroxyl oxacycloalkane derivative can be more efficiently synthesized.

A S - (+) -3 - hydroxy tetrahydrofuran chemical synthesis method

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Paragraph 0023-0025, (2019/04/04)

The invention discloses a S - (+) - 3 - hydroxy tetrahydrofuran chemical synthesis method, includes the following operation steps: 1, compound 1 in the presence of thionyl chloride and methanol reaction to obtain compound 2; 2, in the solvent, compound 2 in the presence of a reducing agent and the reaction to obtain compound 3; 3, compound 3 in the presence of paratoluene sulfonic acid, reaction to obtain compound S - (+) - 3 - hydroxy tetrahydrofuran.

Preparation method of (s)-3-hydroxytetrahydrofuran

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Paragraph 0032; 0037-0039; 0044-0046; 0051-0053; 0058-0060, (2019/11/13)

The invention provides a preparation method of (s)-3-hydroxytetrahydrofuran. According to the preparation method, ethyl 4-chloroacetoacetate is taken as an initial raw material, (s)-4-chloro-3 hydroxyl-1-butanol is prepared, wherein a substrate is dissolved in a first solvent, an alkali is added, under the catalytic effect of a first catalyst and a second catalyst, asymmetric hydrogenation reaction with hydrogen gas is carried out to produce (s)-4-chloro-3 hydroxyl-1-butanol; chiral 3-hydroxytetrahydrofuran is prepared, wherein prepared chiral 4-chloro-3 hydroxyl-1-butanol is dissolved in a second solvent, an acid is added as a catalyst, and reaction is carried out to obtain (s)-3-hydroxytetrahydrofuran; wherein the first catalyst is a complex generated through reaction of [Ir(COD)Cl]2 with phosphine-pyridine ligand, and the second catalyst is Ru-MACHO complex. The reaction route is short; technology is simple; raw materials are cheap and easily available; production cost is low; reaction process environment pollution is low; product optical purity is high; and the preparation method is suitable for industrialized production.

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