849216-79-1

Basic information

• Product Name: ((4-BROMOPHENYL)SULFONYL)(2-INDOL-3-YLETHYL)AMINE
• Synonyms: ((4-BROMOPHENYL)SULFONYL)(2-INDOL-3-YLETHYL)AMINE;4-Bromo-N-[2-(1H-indol-3-yl)ethyl]benzenesulfonamide
• CAS NO: 849216-79-1
• Molecular Formula: C₁₆H₁₅BrN₂O₂S
• Molecular Weight: 379.27
• Mol File: 849216-79-1.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ((4-BROMOPHENYL)SULFONYL)(2-INDOL-3-YLETHYL)AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: ((4-BROMOPHENYL)SULFONYL)(2-INDOL-3-YLETHYL)AMINE(849216-79-1)
• EPA Substance Registry System: ((4-BROMOPHENYL)SULFONYL)(2-INDOL-3-YLETHYL)AMINE(849216-79-1)

Safety Data

• Hazardous Substances Data: 849216-79-1(Hazardous Substances Data)

Usage

General Description

(4-Bromophenyl)sulfonyl)(2-indol-3-ylethyl)amine is a chemical compound that consists of a 4-bromophenyl group attached to a sulfonamide group, which in turn is attached to a 2-indol-3-ylethylamine group. ((4-BROMOPHENYL)SULFONYL)(2-INDOL-3-YLETHYL)AMINE is a potential drug molecule with unique structural features that may have applications in pharmaceutical research and development. It may possess biological activity and chemical reactivity that could make it useful in the treatment of certain diseases or conditions. Further research and testing are necessary to fully understand the potential of this compound.

Upstream product

• 61-54-1 tryptamine 
• 98-58-8 4-bromobenzenesulfonyl chloride 

Relevant articles and documents

Evaluation and docking of indole sulfonamide as a potent inhibitor of α-glucosidase enzyme in streptozotocin –induced diabetic albino wistar rats

We have synthesized new hybrid class of indole bearing sulfonamide scaffolds (1–17) as α-glucosidase inhibitors. All scaffolds were found to be active except scaffold 17 and exhibited IC50 values ranging from 1.60 to 51.20 μM in comparison with

Small-molecule inhibitors that target protein-protein interactions in the RAD51 family of recombinases

The development of small molecules that inhibit protein-protein interactions continues to be a challenge in chemical biology and drug discovery. Herein we report the development of indole-based fragments that bind in a shallow surface pocket of a humanised surrogate of RAD51. RAD51 is an ATP-dependent recombinase that plays a key role in the repair of doublestrand DNA breaks. It both self-associates, forming filament structures with DNA, and interacts with the BRCA2 protein through a common "FxxA" tetrapeptide motif. We elaborated previously identified fragment hits that target the FxxA motif site and developed small-molecule inhibitors that are approximately 500-fold more potent than the initial fragments. The lead compounds were shown to compete with the BRCA2-derived Ac-FHTA-NH2 peptide and the self-association peptide of RAD51, but they had no effect on ATP binding. This study is the first reported elaboration of small-molecular-weight fragments against this challenging target.

Indole-3-ethylsulfamoylphenylacrylamides: Potent histone deacetylase inhibitors with anti-inflammatory activity

A series of 2-methyl-1H-indol-3-ethylsulfamoylphenylacrylamides based on LBH589-PXD101 core have been synthesized and evaluated for their histone deacetylase (HDAC) inhibitory and anti-inflammatory activity. In vitro, compounds 9-12 show 2.6-fold better H