84923-30-8 Usage
Structure
Contains an amino group, a methoxy group, and a pyrimidine-5-carboxamide group, a bicyclic octane ring, and a methoxyphenylmethyl group
Biological and pharmaceutical significance
Potential candidate for drug development, potential applications in medicinal chemistry and pharmacology, potential therapeutic uses
Check Digit Verification of cas no
The CAS Registry Mumber 84923-30-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,4,9,2 and 3 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 84923-30:
(7*8)+(6*4)+(5*9)+(4*2)+(3*3)+(2*3)+(1*0)=148
148 % 10 = 8
So 84923-30-8 is a valid CAS Registry Number.
InChI:InChI=1/C21H27N5O3/c1-28-18-6-4-3-5-13(18)12-26-15-7-8-16(26)10-14(9-15)24-19(27)17-11-23-21(22)25-20(17)29-2/h3-6,11,14-16H,7-10,12H2,1-2H3,(H,24,27)(H2,22,23,25)
84923-30-8Relevant articles and documents
Studies on the neuroleptic benzamides. III - Synthesis and antidopaminergic properties of new 3-nortropane derivatives
Dostert,Imbert,Langlois,et al.
, p. 105 - 110 (2007/10/02)
Various benzamides prepared from 4-alkoxy pyrimidine 5-carboxylic acids and 3-amino nortropane derivatives have been tested for their potential antipsychotic activity. Two compounds exhibited pharamacological activity equivalent to that of haloperidol but had lower toxicity and lower potency to induced catalepsy. Antidopaminergic activity is observed mainly in compounds in which the nortropane ring is substituted in the equatorial position, having a benzyl substituent on the basic nitrogen. The influence of electron attractor or donor substituents carried by the benzyl ring has been evaluated. Some aspects of structure-activity relationships are discussed.