849241-58-3Relevant academic research and scientific papers
Nonpolar and short side chain groups at C-11β of estradiol result in antiestrogens
Zhang, Jing-Xin,Labaree, David C.,Hochberg, Richard B.
, p. 1428 - 1447 (2007/10/03)
We have previously found that esters of 11β-estradiol carboxylates are transformed from an estrogen into an antiestrogen when the 11β-side chain is increased in length from four to five non-hydrogen atoms (n ≥ 5). To understand the structural requirements
11beta-short chain substituted estradiol analogs and their use in the treatment of menopausal symptoms and estrogen sensitive cancer
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Page/Page column sheet 10, (2010/02/07)
The present invention relates to novel 11-β estradiol ester compounds and their use as locally active estrogens in the treatment of the symptomology of menopause and to treat estrogen sensitive cancers, including breast cancer.
