849243-26-1Relevant articles and documents
Discovery and synthesis of a potent, selective and orally bioavailable EP4 receptor agonist
Young, Robert N.,Billot, Xavier,Han, Yongxin,Slipetz, Deborah A.,Chauret, Nathalie,Belley, Michel,Metters, Kathleen,Mathieu, Marie-Claude,Greig, Gillian M.,Denis, Danielle,Girard, Mario
, p. 437 - 446 (2004)
An optimized analog of prostaglandin E2 which incorporates a γ-lactam in place of the cyclopentanone ring and which incorporates metabolically stabilized side chains, has been identified and shown to exhibit potent and selective EP4 receptor ag
1,5-DISTRIBUTED PYRROLID-2-ONE DERIVATIVES FOR USE AS EP4 RECEPTOR AGONISTS IN THE TREATMENT OF EYE DISEASES SUCH AS GLAUCOMA
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Page 43-44, (2008/06/13)
This invention relates to potent selective agonists of the EP4 subtype of prostaglandin E2 receptors of formula (I), their use or a formulation thereof in the treatment of glaucoma and other conditions which are related to elevated intraocular pressure in the eye of the patient.