849341-09-9

Upstream product

• 947689-44-3 N-(2-iodophenyl)-N-tert-butoxycarbonyl-2-propynylamine 
• 533-58-4 2-Iodophenol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 615-43-0 2-iodophenylamine 
• 161117-84-6 tert-butyl 2-iodophenylcarbamate 
• 870703-53-0 N-di(tert-butylcarboxy)aniline 

Downstream Products

• 1234580-69-8 tert-butyl 3-(3-phenylprop-2-yn-1-yl)-1H-indole-1-carboxylate 

Relevant academic research and scientific papers

Asymmetric Domino Heck/Dearomatization Reaction of β-Naphthols to Construct Indole-Terpenoid Frameworks

A palladium-catalyzed enantioselective Heck cyclization/dearomatization cascade via capturing the cyclized Heck π-allylpalladium intermediate by β-naphthols is reported, which provides a new strategy for the construction of chiral indole-terpenoid framewo

Palladium-Catalyzed Domino Allenamide Carbopalladation/Direct C-H Allylation of Heteroarenes: Synthesis of Primprinine and Papaverine Analogues

Palladium-catalyzed intramolecular carbopalladation onto allenamides completed by direct C-H allylation of heterocycles is studied. The domino construction/heteroarylation of isoquinolone process is first achieved. A general three-step one-pot strategy, i

Palladium-Catalyzed Intramolecular Arylative Carboxylation of Allenes with CO2 for the Construction of 3-Substituted Indole-2-carboxylic Acids

Arylative carboxylation of allenes proceeded in an intramolecular manner to afford the corresponding β,γ-unsaturated carboxylic acids in high yields using PdCl2/PAr3 (Ar = C6H4-p-CF3) and ZnEt2 under 1 atm of CO2. The intermediate of the cyclization/carboxylation sequence is thought to be a nucleophilic η1-allylethylpalladium, which reacts with CO2 at the γ-position of palladium. The products obtained could be efficiently converted into 3-substituted indole-2-carboxylate derivatives. One-pot synthesis of strychnocarpine, a β-carboline alkaloid, from the carboxylated product was also demonstrated.

An approach to cyclohepta[ b ]indoles through an allenamide (4 + 3) cycloaddition-grignard cyclization-chugaev elimination sequence

A strategy for synthesizing highly functionalized cyclohepta[b]indoles through a concise (4 + 3) cycloaddition-cyclization-elimination sequence is described. The cycloaddition features nitrogen-stabilized oxyallyl cations derived from epoxidations of N-ar

A strategy for the synthesis of 2,3-disubstituted indoles starting from N-(o-halophenyl)allenamides

A strategy for the synthesis of 2,3-disubstituted indole derivatives based on an intramolecular carbopalladation-anion capture cascade has been developed, wherein construction of the pyrrole ring and functionalisation of the indole C2 and C3 positions wer

Highly regioselective radical cyclizations of allenamides

(Chemical Equation Presented) The first radical cyclizations of allenamides are described. These reactions are highly regioselective for the central carbon of the allenic moiety, leading to an efficient preparation of nitrogen heterocycles such as isoquin