849348-49-8Relevant academic research and scientific papers
5-sulfonamide benzimidazoles: A class of cannabinoid receptors agonists with potent in vivo antinociception activity
Page, Daniel,Wei, Zhongyong,Liu, Ziping,Tremblay, Maxime,Desfosses, Helene,Milburn, Claire,Srivastava, Sanjay,Yang, Hua,Brown, William,Walpole, Christopher,Tomaszewski, Mirek,St-Onge, Stephane,Lessard, Etienne,Payza, Kemal,Panetta, Rosemarie,Yu, Xiao Hong,Groblewski, Thierry
scheme or table, p. 208 - 213 (2011/02/21)
The synthesis and biological evaluation of a novel class of cannabinoid receptor agonists based on a 5-sulfonamide benzimidazole scaffold are reported. They showed a high binding affinity to both receptors with great in vivo potency. When given orally to
BENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM, PREPARATION THEREOF AND USES THEREOF
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Page/Page column 85-86, (2010/02/11)
Compounds of Formula (I) or pharmaceutically acceptable salts thereof; wherein R1, R2, R3, R4, n and Ar are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
BENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM, PREPARATION THEREOF AND USES THEREOF
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Page/Page column 54-55, (2010/02/11)
Compounds of Formula (I) or pharmaceutically acceptable salts thereof; wherein R1, R2, R3 and Ar are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.
