849359-56-4 Usage
Uses
Used in Pharmaceutical Synthesis:
3,5-diiodo-4-methoxypyridine is used as a key intermediate in the production of pharmaceuticals for its ability to be incorporated into the molecular structures of various drugs. Its presence can influence the pharmacological properties of the final product, enhancing their therapeutic effects.
Used in Agrochemical Production:
In the agrochemical industry, 3,5-diiodo-4-methoxypyridine is utilized as a building block in the synthesis of compounds that have pesticidal or herbicidal properties. Its iodinated and methoxylated structure contributes to the effectiveness of these agrochemicals in controlling pests and weeds.
Used in Organic Chemistry Research:
3,5-diiodo-4-methoxypyridine serves as a valuable compound in organic chemistry research, where it is employed to study reaction mechanisms and to develop new synthetic methodologies. Its reactivity with various reagents allows for the exploration of novel chemical transformations.
Used in Drug Discovery:
3,5-diiodo-4-methoxypyridine is used as a potential anticancer agent in drug discovery. Its unique structural features are being investigated for their ability to target and affect biological pathways involved in cancer progression, offering a new avenue for the development of anticancer therapeutics.
Check Digit Verification of cas no
The CAS Registry Mumber 849359-56-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,4,9,3,5 and 9 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 849359-56:
(8*8)+(7*4)+(6*9)+(5*3)+(4*5)+(3*9)+(2*5)+(1*6)=224
224 % 10 = 4
So 849359-56-4 is a valid CAS Registry Number.
InChI:InChI=1/C6H5I2NO/c1-10-6-4(7)2-9-3-5(6)8/h2-3H,1H3
849359-56-4Relevant academic research and scientific papers
Hedidi, Madani,Bentabed-Ababsa, Ghenia,Derdour, A?cha,Halauko, Yury S.,Ivashkevich, Oleg A.,Matulis, Vadim E.,Chevallier, Floris,Roisnel, Thierry,Dorcet, Vincent,Mongin, Florence
, p. 2196 - 2205 (2016)
A series of methoxy- and fluoro-pyridines have been deprotometalated in tetrahydrofuran at room temperature by using a mixed lithium-zinc combination obtained from ZnCl2·TMEDA (TMEDA=N,N,N′,N′-tetramethylethylenediamine) and LiTMP (TMP=2,2,6,6-tetramethylpiperidino) in a 1:3 ratio, and the metalated species intercepted by iodine. Efficient functionalization at the 3 position was observed from 4-methoxy, 2-methoxy, 2,6-dimethoxy, 2-fluoro and 2,6-difluoropyridine, and at the 4 position from 3-methoxy and 2,3-dimethoxypyridine. Interestingly, clean dideprotonation was noted from 3-fluoropyridine (at C2 and C4) and 2,6-difluoropyridine (at C3 and C5). The obtained regioselectivities have been discussed in light of the CH acidities of the substrates, determined both in the gas phase (DFT B3LYP and G3MP2B3 levels) and in THF solution. In the case of methoxypyridines, the pKa values have also been calculated for complexes with LiCl and LiTMP.
