849367-92-6

Upstream product

• 874-60-2 4-methyl-benzoyl chloride 
• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 
• 496784-98-6 1-(2-hydroxy-4-methoxyphenyl)-3-(4-methylphenyl)-1,3-propanedione 
• 849367-91-5 4-methylbenzoic acid 2'-acetyl-5'-methoxyphenyl ester 

Downstream Products

• 329727-22-2 2-(4-formylphenyl)-7-methoxy-4H-1-benzopyran-4-one 

Relevant academic research and scientific papers

Extensive SAR and computational studies of 3-{4-[(benzylmethylamino)methyl] phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) derivatives

AP2238 was the first compound published to bind both anionic sites of the human acetylcholinesterase, allowing the simultaneous inhibition of the catalytic and the amyloid-β pro-aggregating activities of AChE. Here we attempted to derive a comprehensive structure-activity relationship picture for this molecule, affording 28 derivatives for which AChE and BChE inhibitory activities were evaluated. Selected compounds were also tested for their ability to prevent the AChE-induced Aβ-aggregation. Moreover, docking simulations and molecular orbital calculations were performed.

Synthesis and potent antimicrobial activity of some novel 2-phenyl or methyl-4H-1-benzopyran-4-ones carrying amidinobenzimidazoles

Series of flavones and methyl-4H-1-benzopyran-4-ones carrying mono or diamidinobenzimidazoles at different positions were synthesized and evaluated for antibacterial and antifungal activities against E. coli, S. aureus, MRSA (methicillin-resistant S. aure