849405-24-9Relevant academic research and scientific papers
2,7-Dihydro-3H-pyridazino[5,4,3-kl]acridin-3-one derivatives, novel type of cytotoxic agents active on multidrug-resistant cell lines. Synthesis and biological evaluation
Stefanska, Barbara,Bontemps-Gracz, Maria M.,Antonini, Ippolito,Martelli, Sante,Arciemiuk, Malgorzata,Piwkowska, Agnieszka,Rogacka, Dorota,Borowski, Edward
, p. 1969 - 1975 (2005)
We have earlier postulated that the presence of a pyridazone ring fused with an anthracenedione moiety resulted in the analog's ability to overcome multidrug resistance of tumor cells [J. Med. Chem. 1999, 42, 3494]. High cytotoxic activity of obtained ant
