849409-82-1

Basic information

• Product Name: 3-(Propane-1-sulfonaMido)benzoic acid
• Synonyms: 3-(Propane-1-sulfonaMido)benzoic acid;3-(Propane-1-sulfonylamino)-benzoic acid
• CAS NO: 849409-82-1
• Molecular Formula: C₁₀H₁₃NO₄S
• Molecular Weight: 243.27952
• Mol File: 849409-82-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(Propane-1-sulfonaMido)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(Propane-1-sulfonaMido)benzoic acid(849409-82-1)
• EPA Substance Registry System: 3-(Propane-1-sulfonaMido)benzoic acid(849409-82-1)

Safety Data

• Hazardous Substances Data: 849409-82-1(Hazardous Substances Data)

Upstream product

• 4518-10-9 Methyl 3-aminobenzoate 
• 10147-36-1 n-propanesulfonyl chloride 
• 121-92-6 3-nitrobenzoic acid 
• 618-95-1 methyl 3-nitrobenzoate 
• 849409-81-0 3-(propane-1-sulfonylamino)-benzoic acid ethyl ester 

Relevant articles and documents

Demonstrating Ligandability of the LC3A and LC3B Adapter Interface

Autophagy is the common name for a number of lysosome-based degradation pathways of cytosolic cargos. The key components of autophagy are members of Atg8 family proteins involved in almost all steps of the process, from autophagosome formation to their selective fusion with lysosomes. In this study, we show that the homologous members of the human Atg8 family proteins, LC3A and LC3B, are druggable by a small molecule inhibitor novobiocin. Structure-activity relationship (SAR) studies of the 4-hydroxy coumarin core scaffold were performed, supported by a crystal structure of the LC3A dihydronovobiocin complex. The study reports the first nonpeptide inhibitors for these protein interaction targets and will lay the foundation for the development of more potent chemical probes for the Atg8 protein family which may also find applications for the development of autophagy-mediated degraders (AUTACs).

PROTEIN KINASE INHIBITORS FOR PROMOTING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH

The invention relates to compounds of formula (I) which are inhibitors of MKK4 (mitogen-activated protein kinase kinase 4) and their use in promoting liver regeneration or reducing or preventing hepatocyte death. The compounds selectively inhibit protein kinase MKK4 over protein kinases JNK and MKK7. (I), wherein R x, R y , R z and R zz are selected from: a) R x and R y are F and R z and R zz are H; b) R x, R y and R zz are independently halogen and R z is H; c) R x R z and R zz are independently halogen and R y is H; and d) R x R y and R z are independently halogen and R zz is H

NOVEL SULFONE AMIDE DERIVATIVES CAPABLE OF INHIBITING BACE

The present invention relates to novel derivatives of sulfone amide of Formula 1 as defined in this disclosure which inhibit the activity of BACE (or beta-secretase). These sulfone amide derivatives are useful for the treatment and prevention of Alzheimer's disease and related diseases caused by production of beta-amyloid, by inhibiting the activity of BACE.