84941-15-1

Usage

Derivative of benzimidazole

A bicyclic aromatic compound

Difluoromethyl group

Attached to the benzimidazole ring

Usage

Pharmaceutical and agricultural industries

Applications

Development of pharmaceutical drugs and agrochemicals

Unique chemical properties

Potentially imparted by the difluoromethyl group

Biological activity

Potentially useful for medicinal purposes

Further research needed

To understand and utilize properties and potential applications

Specific content

1. 1H-Benzimidazole,1-(difluoromethyl)-(9CI) is a chemical compound with a molecular formula of C8H6F2N2.
2. It is a derivative of benzimidazole, which is a bicyclic aromatic compound.
3. The compound is characterized by the presence of a difluoromethyl group attached to the benzimidazole ring.
4. It is used in the pharmaceutical industry for the development of various pharmaceutical drugs.
5. It is also used in the agricultural industry for the development of agrochemicals.
6. The difluoromethyl group can potentially impart unique chemical properties to the compound, making it useful for a range of applications.
7. The compound may have biological activity, which makes it potentially useful for medicinal purposes.
8. Further research and testing are likely needed to fully understand and utilize the properties and potential applications of 1H-Benzimidazole,1-(difluoromethyl)-(9CI).

Upstream product

• 51-17-2 benzoimidazole 
• 667-27-6 Ethyl bromodifluoroacetate 
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• 1895-39-2 sodium chlorodifluoroacetate 
• 613-94-5 benzoic acid hydrazide 

Relevant academic research and scientific papers

Synthesis of Difluorinated Heterocyclics through Metal-Free [8+1] and [4+1] Cycloaddition of Difluorocarbene

With Ph3P+CF2COO- or TMSCF2Br as the difluorocarbene sources, a facile metal-free cycloaddition between heteroconjugated alkenes and difluorocarbene was developed for the highly convergent synthesis of novel difluorinated heterocyclics, including gem-difluorinated azetidines and 2,3-dihydrobenzofurans. The cycloaddition features high reactivity and regioselectivity, as well as good tolerance of various electron-donating or electron-withdrawing substituents on azaheptafulvenes and o-quinone methides.

[4u202f+u202f1] Cyclization of benzohydrazide and ClCF2COONa towards 1,3,4-oxadiazoles and 1,3,4-oxadiazoles-d5

A facile synthesis of 1,3,4-oxadiazoles and 1,3,4-oxadiazoles-d5 via [4 + 1] cyclization of ClCF2COONa with non-amine compounds containing amino groups is developed. Of note, this is the first time that halofluorinated compounds are used as C1 synthon to construct deuterated nitrogen-heterocyclic compounds. The current protocol features simple operation, readily accessible raw materials, wide substrate scope and valuable products

Transition metal-free assembly of 1,3,5-triazines using ethyl bromodifluoroacetate as C1 source

An efficient transition metal-free annulation of amidine with ethyl bromodifluoroacetate to access 2,4-disubstituted-1,3,5-triazines is firstly presented. The desired symmetric and unsymmetric 2,4-disubstituted-1,3,5-triazines were obtained in decent yields via multiple C-N bond formation, in which ethyl bromodifluoroacetate is harnessed as a unique C1 synthon via quadruple cleavage. This reaction is transition metal-free, oxidant-free and simple in operation, and only lowly toxic inorganic wastes are generated.

An efficient method for the N-formylation of amines under catalyst- and additive-free conditions

A simple catalyst- and additive-free method for the N-formylation of amines has been developed. The advantages of this protocol include a wide range of functional group tolerance, high efficiency and a lack of required extra promoters under mild conditions. This convenient strategy will provide a facile synthesis towards N-formamide natural products and pharmaceutical derivatives. A mechanism that involves difluorocarbene is proposed for this reaction.