849487-96-3Relevant academic research and scientific papers
The efficient synthesis of (3R,4R,5R)-3-amino-4,5-dimethyl-octanoic acid, a chiral β-amino acid with potent affinity for the α2δ protein
Zhang, Ji,Blazecka, Peter G.,Pflum, Derek A.,Bozelak, Joseph,Vrieze, Derek,Colbry, Norman L.,Hoge, Garrett,Boyles, David C.,Samas, Brian,Curran, Timothy T.,Osuma, Augustine T.,Johnson, Paul,Kesten, Suzanne,Schwarz, Jacob B.,Goodman, Annise,Plummer, Mark,Akin, Anne,Huang, Yun,Lovdahl, Michael,Thorpe, Andrew J.
, p. 1167 - 1170 (2009)
A chiral β-amino acid containing three contiguous chiral centers was synthesized efficiently in 11 steps, employing enantio-enriched β-ketoester as a key intermediate, via stereoselective catalytic hydrogenation of the corresponding enamide. Stereoselecti
METHODS OF TREATMENT USING ALPHA-2-DELTA-1 SELECTIVE COMPOUNDS
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Page/Page column 15, (2008/06/13)
The invention is directed to a method of treating a disorder or condition using an alpha-2-delta ligand with high affinity and selectivity for the alpha-2-delta-1 calcium channel subunit subtype. Administration of the alρha-2-delta-1 selective ligand, or
AMINO ACIDS WITH AFFINITY FOR THE ALPHA2DELTA-PROTEIN
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, (2010/02/11)
Certain ?-amino acids that bind to the alpha-2-delta (a2S) subunit of a calcium channel are disclosed. These compounds and their pharmaceutically acceptable salts are useful in the treatment of a variety of psychiatric, pain and other disorders.
