849599-99-1

Upstream product

• 849600-50-6 N-[5-chloro-3-methyl-6-(2,4,6-trifluorophenyl)[1,2,4]triazolo[1,5-a]pyrimidin-7(3H)-ylidene]-2,2,2-trifluoroethanamine 

Downstream Products

• 849600-27-7 4-chloro-5-{4-[3-(dimethylamino)propoxy]-2,6-difluorophenyl}-6-[(2,2,2-trifluoroethyl)amino]pyrimidin-2-yl(methyl)cyanamide 
• 1245536-75-7 6-chloro-5-{4-[3-(dimethylamino)propoxy]-2,6-difluorophenyl}-N₂-methyl-N₄-(2,2,2-trifluoroethyl)pyrimidine-2,4-diamine trifluoroacetic acid salt 

Relevant academic research and scientific papers

2-Cyanoaminopyrimidines as a class of antitumor agents that promote tubulin polymerization

A series of 4-chloro-2-cyanoamino-6-fluoroalkylamino-5-phenylpyrimidines was prepared as a result of our efforts to modify a series of [1,2,4]triazolo[1,5-a]pyrimidines that proved to be potent anticancer agents with a unique mechanism of tubulin inhibiti

5-arylpyrimidines as anticancer agents

This invention relates to certain 5-arylpyrimidine compounds or a pharmaceutically acceptable salt thereof, and compositions containing said compounds or a pharmaceutically acceptable salt thereof, wherein said compounds are anti-cancer agents useful for