Cas 849600-40-4,6-chloro-5-(2,6-difluoro-4-[3-(methylamino)propoxy]-phenyl)-2-pyridin-2-yl-N-[(1S)-2,2,2-trifluoro-1-methylethyl]-pyrimidin-4-amine

849600-40-4

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Basic information

Product Name: 6-chloro-5-(2,6-difluoro-4-[3-(methylamino)propoxy]-phenyl)-2-pyridin-2-yl-N-[(1S)-2,2,2-trifluoro-1-methylethyl]-pyrimidin-4-amine
Synonyms:
CAS NO:849600-40-4
Molecular Formula:
Molecular Weight: 501.887
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: 6-chloro-5-(2,6-difluoro-4-[3-(methylamino)propoxy]-phenyl)-2-pyridin-2-yl-N-[(1S)-2,2,2-trifluoro-1-methylethyl]-pyrimidin-4-amine(CAS DataBase Reference)
NIST Chemistry Reference: 6-chloro-5-(2,6-difluoro-4-[3-(methylamino)propoxy]-phenyl)-2-pyridin-2-yl-N-[(1S)-2,2,2-trifluoro-1-methylethyl]-pyrimidin-4-amine(849600-40-4)
EPA Substance Registry System: 6-chloro-5-(2,6-difluoro-4-[3-(methylamino)propoxy]-phenyl)-2-pyridin-2-yl-N-[(1S)-2,2,2-trifluoro-1-methylethyl]-pyrimidin-4-amine(849600-40-4)

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RTECS:
HazardClass: N/A
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Hazardous Substances Data: 849600-40-4(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 849600-40-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,4,9,6,0 and 0 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 849600-40:
(8*8)+(7*4)+(6*9)+(5*6)+(4*0)+(3*0)+(2*4)+(1*0)=184
184 % 10 = 4
So 849600-40-4 is a valid CAS Registry Number.

849600-40-4Upstream product

42055-15-2 N-methyl-3-hydroxypropylamine

849600-40-4Downstream Products

849600-40-4Relevant academic research and scientific papers

HETEROCYCLIC COMPOUNDS AND THEIR USE FOR THE TREATMENT OF NEURODEGENERATIVE TAUOPATHIES

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Paragraph 0113; 0139, (2014/04/04)

The present invention is directed to triazolopyrimidine, phenylpyrimidine, pyridopyridazine, and pyridotriazine compounds and their use in the treatment of neurodegenerative disorders.

Synthesis and SAR of 6-chloro-4-fluoroalkylamino-2-heteroaryl-5-(substituted)phenylpyrimidines as anti-cancer agents

Zhang, Nan,Ayral-Kaloustian, Semiramis,Nguyen, Thai,Hernandez, Richard,Lucas, Judy,Discafani, Carolyn,Beyer, Carl

experimental part, p. 111 - 118 (2011/02/25)

The synthesis and SAR of a series of 6-chloro-4-fluoroalkylamino-2-heteroaryl-5-(substituted)phenylpyrimidines as anti-cancer agents are described. This series of 2-heteroarylpyrimidines was developed by modifying a series of anti-tumor [1,2,4]triazolo[1,5-a]pyrimidines and 2-cyanoaminopyrimidines we reported earlier. For the 2-heteroaryl group, the best activity is obtained when the heteroaryl group has a nitrogen atom at the ortho-position to the pyrimidyl core. The structure-activity relationship for the rest of the molecule in this 2-heteroarylpyrimidine series mimics that of the [1,2,4]triazolo[1,5-a]pyrimidine series. Like triazolopyrimidines and 2-cyanoaminopyrimidines, the 2-heteroarylpyrimidines retain the capability to overcome multidrug resistance due to Pgp. Mechanism of action studies showed that the lead compounds behaved in the same manner as triazolopyrimidines and 2-cyanoaminopyrimidines. The lead compounds in this series are more potent than the corresponding triazolopyrimidines in vitro and in vivo. Compound 21 (PTI-868) showed tumor growth inhibition in several nude mouse xenograft models, and was selected to advance to preclinical development.

5-arylpyrimidines as anticancer agents

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Page/Page column 41, (2008/06/13)

This invention relates to certain 5-arylpyrimidine compounds or a pharmaceutically acceptable salt thereof, and compositions containing said compounds or a pharmaceutically acceptable salt thereof, wherein said compounds are anti-cancer agents useful for

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