849643-74-9Relevant academic research and scientific papers
Discovery of a novel series of quinolone and naphthyridine derivatives as potential topoisomerase I inhibitors by scaffold modification
You, Qi-Dong,Li, Zhi-Yu,Huang, Chiung-Hua,Yang, Qian,Wang, Xiao-Jian,Guo, Qing-Long,Chen, Xiao-Guang,He, Xun-Gui,Li, Tsai-Kun,Chern, Ji-Wang
, p. 5649 - 5661 (2009)
A novel series of topoisomerase I (Top I) inhibitors were designed on the basis of camptothecin using scaffold modification strategy. Thirty-one new compounds were synthesized and evaluated for anticell proliferation activity. The most potent compound 26
