849669-20-1Relevant articles and documents
Synthesis of gem-difluorocyclopentane/hexane building blocks
Melnykov, Kostiantyn P.,Nosik, Pavel S.,Kurpil, Bohdan B.,Sibgatulin, Dmitriy A.,Volochnyuk, Dmitriy M.,Ryabukhin, Sergey V.,Grygorenko, Oleksandr O.
, p. 60 - 66 (2017/05/17)
An approach to the preparation of gem-difluorocyclopentane/hexane-derived carboxylic acids and amines is described. Whereas for 3,3-difluoro-substituted cycloalkanones, straightforward deoxofluorination of the corresponding ketoesters led to the target compounds, in the case of 2,2-difluoro isomers, the bypass or alternative routes were necessary.
Synthesis method of 3,3-difluorocyclohexyl methylamine
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, (2018/02/04)
The invention discloses a synthesis method of 3,3-difluorocyclohexyl methylamine, belonging to the technical field of synthesis of fluorocyclohexyl methylamine. The technical scheme is as follows: the synthesis method comprises the following steps: synthesis of ethyl 3,3-difluorocyclohexylformate, synthesis of 3,3-difluorocyclohexylformic acid, synthesis of 3,3-difluorocyclohexyl ethanol and synthesis of 3,3-difluorocyclohexyl methylamine. The reaction equation is disclosed in the specification. Compared with the prior art, the method has the advantages of low cost, lower toxicity and higher yield, and can easily implement industrialization.
