849669-39-2Relevant academic research and scientific papers
3-Arylidene-1-(4-nitrophenylmethylene)-3,4-dihydro-1H-naphthalen-2-ones and related compounds displaying selective toxicity and reversal of multidrug resistance in neoplastic cells
Dimmock, Jonathan R.,Das, Umashankar,Gul, H. Inci,Kawase, Masami,Sakagami, Hiroshi,Barath, Zoltan,Ocsovsky, Imre,Molnar, Joseph
, p. 1633 - 1636 (2005)
The incorporation of the 1-aryl-5-(4-nitrophenyl)-3-oxo-1,4-pentadienyl group into 3,4-dihydro-1H-naphthalenyl, cyclohexyl, 2,3-dihydro-1H-indenyl and cyclopentyl scaffolds led to the discovery of various compounds with selective toxicity for malignant cells and ability to reverse multidrug resistance.
Cytotoxic 5-aryl-1-(4-nitrophenyl)-3-oxo-1,4-pentadienes mounted on alicyclic scaffolds
Das, Umashankar,Gul, H. Inci,Alcorn, Jane,Shrivastav, Anuraag,George, Theresa,Sharma, Rajendra K.,Nienaber, Kurt H.,De Clercq, Erik,Balzarini, Jan,Kawase, Masami,Kan, Noriyuki,Tanaka, Toru,Tani, Satoru,Werbovetz, Karl A.,Yakovich, Adam J.,Manavathu, Elias K.,Stables, James P.,Dimmock, Jonathan R.
, p. 577 - 585 (2007/10/03)
The 5-aryl-1-(4-nitrophenyl)-3-oxo-1,4-pentadienyl pharmacophore was incorporated into four series of compounds 1-4. Compounds 1a-g comprised a cluster of 3-arylidene-1-(4-nitrophenylmethylene)-2-oxo-3,4-dihydro-1H-naphthalenes while the analogues 2a-g co
