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Relevant academic research and scientific papers

Nonpolar thymidine analogs

Nonpolar thymidine analogs are provided comprising a dihalogenated or trihalogenated base of the structure: where R1 is a sugar moiety; R2 is H or CH3; an imaging moiety or a cytotoxic moiety and X1 and X2

A series of nonpolar thymidine analogues of increasing size: DNA base pairing and stacking properties

(Chemical Equation Presented) We describe the properties in DNA of a set of five nonpolar nucleoside mimics in which shape is similar but size is increased gradually. The compounds vary in the size of their exocyclic substituents, which range from hydroge