84968-04-7

Usage

Type of compound

Halogenated pyrazole derivative

Industry use

Pharmaceutical industry (building block for synthesis of bioactive compounds)

Additional use

Reagent in organic synthesis (preparation of heterocyclic compounds)

Key functional group

Chloromethyl group

Versatility

Acts as a versatile intermediate for the synthesis of various derivatives

Potential applications

Agrochemicals and materials science

Safety precautions

Handle with care, potential irritant, use in well-ventilated environment with appropriate protective equipment

Upstream product

• 1120-82-7 pyrazole-1-methanol 

Downstream Products

• 80200-19-7 4-(Pyrazol-1-ylmethylsulfanyl)-phenol 

Relevant academic research and scientific papers

New arylselanylpyrazole-copper catalysts: Highly efficient catalytic system for C–Se and C–S coupling reactions

We describe herein the use of arylselanylpyrazole–copper complexes as versatile catalysts for C–Se and C–S coupling reactions. The performance of these complexes for C–Se reactions was investigated in chalcogenoacetylene synthesis. The reactions were carried out under mild and aerobic conditions and afforded selanylalkynes bearing a variety of electron-withdrawing and electron-donating groups. The performance of these catalysts for C–S coupling was investigated through the reaction of aryl halides with thiols and products were obtained in moderate to excellent yields. A plausible mechanism for selenoacetylene synthesis is also suggested, and the 77Se NMR results show that these arylselanylpyrazole ligands act as hemilabile ligands. High-resolution mass spectrometry was used to investigate the intermediates and also to corroborate the proposed catalytic cycle.