849682-32-2

Upstream product

• 20099-90-5 4-(2-bromoacetyl)benzoic acid 
• 849682-31-1 (4-methylpiperazin-1-yl)thiourea 
• 6928-85-4 N-amino-N'-methylpiperazine 
• 586-89-0 4-acetyl-benzoic acid 

Relevant academic research and scientific papers

3,4-Disubstituted azetidinones as selective inhibitors of the cysteine protease cathepsin K. Exploring P3 elements for potency and selectivity

The synthesis of a series of highly potent and selective inhibitors of cathepsin K based on the 3,4-disubstituted azetidin-2-one warhead is reported. A high degree of potency and selectivity was achieved by introducing a basic nitrogen into the distal par