849727-16-8

Basic information

• Product Name: Thiazole, 2-[(2-fluorophenyl)methyl]-4,5-dihydro-4-phenyl-, (4S)-
• CAS NO: 849727-16-8
• Molecular Formula: C16H14FNS
• Molecular Weight: 271.358
• Mol File: 849727-16-8.mol

Chemical Properties

• CAS DataBase Reference: Thiazole, 2-[(2-fluorophenyl)methyl]-4,5-dihydro-4-phenyl-, (4S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Thiazole, 2-[(2-fluorophenyl)methyl]-4,5-dihydro-4-phenyl-, (4S)-(849727-16-8)
• EPA Substance Registry System: Thiazole, 2-[(2-fluorophenyl)methyl]-4,5-dihydro-4-phenyl-, (4S)-(849727-16-8)

Safety Data

• Hazardous Substances Data: 849727-16-8(Hazardous Substances Data)

Upstream product

• 849727-15-7 2-(2-fluoro-phenyl)-N-(2-hydroxy-1-phenyl-ethyl)-acetamide 
• 451-82-1 (2-fluorophenyl)acetic acid 
• 56613-80-0 D-2-phenylglycinol 

Downstream Products

• 496927-37-8 8-(2-fluoro-phenyl)-3-phenyl-2,3-dihydro-thiazolo[3,2-c]pyrimidine-5,7-dione 

Relevant articles and documents

Efficient synthesis of bicyclic oxazolino- and thiazolino[3,2-c]pyrimidine- 5,7-diones and its application to the synthesis of GnRH antagonists

Treatment of various 2-methyl oxazolines or thiazolines with chlorocarbonyl isocyanate gives the corresponding bicyclic oxazolino- or thiazolino[3,2-c] pyrimidin-5,7-dione derivatives in very good yield. This reaction has been applied to the rapid syntheses of human gonadotropin-releasing hormone (hGnRH) receptor antagonists for SAR study, resulting in 13e with binding affinity in the low nanomolar range (4.5 nM).