849761-82-6

Basic information

• Product Name: Phenol, 2-methyl-6-[(4-methylphenyl)sulfonyl]-
• CAS NO: 849761-82-6
• Molecular Formula: C14H14O3S
• Molecular Weight: 262.329
• Mol File: 849761-82-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Phenol, 2-methyl-6-[(4-methylphenyl)sulfonyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 2-methyl-6-[(4-methylphenyl)sulfonyl]-(849761-82-6)
• EPA Substance Registry System: Phenol, 2-methyl-6-[(4-methylphenyl)sulfonyl]-(849761-82-6)

Safety Data

• Hazardous Substances Data: 849761-82-6(Hazardous Substances Data)

Upstream product

• 599-75-7 2-methylphenyl tosylate 
• 104-15-4 toluene-4-sulfonic acid 
• 95-48-7 ortho-cresol 
• 10486-08-5 sodium p-thiocresolate 
• 109592-46-3 2-methoxy-3-p-tolylsulfanyl-toluene 
• 98-59-9 p-toluenesulfonyl chloride 
• 25922-05-8 2-methyl-6-iodoanisole 
• 108123-10-0 2-methoxy-3-(toluene-4-sulfonyl)-toluene 

Downstream Products

• 108123-10-0 2-methoxy-3-(toluene-4-sulfonyl)-toluene 

Relevant articles and documents

Graphite/methanesulfonic acid (GMA) as a new reagent for sulfonylation of phenols and thia-Fries rearrangement of aryl sulfonates to sulfonylphenols

A new facile method for direct sulfonylation of phenols was developed. Graphite in methanesulfonic acid (GMA) was used to prepare sulfonylphenols by sulfonylation of phenol and naphthalene derivatives with p-toluenesulfonic acid (=4-methylbenzenesulfonic acid) (Table 1) and the thia-Fries rearrangement of aryl sulfonates (Table 4). Mechanistic studies showed that the sulfonylation reaction of phenols in GMA occurred through an initial sulfonate formation followed by a thia-Fries rearrangement of the aryl sulfonate by an intermolecular mechanism (Scheme 3).