849772-62-9Relevant academic research and scientific papers
Synthesis of cobalt-containing monodentate phosphine ligand and application toward Suzuki cross-coupling reactions
Hong, Fung-E,Ho, Yi-Jung,Chang, Yu-Chang,Huang, Yi-Luen
, p. 1249 - 1257 (2005)
A bulky, dicobalt complexed, mono-dentate phosphine, [(μ-PPh 2CH2PPh2)Co2(CO)4](μ, η-PhC≡CPCy2) (4), was prepared from the reactions of the bis(diphenylphosphino)methylene (dppm)-bridged dicobalt complex Co 2(CO)6(μ-Ph2PCH2PPh2) (2) with PhC≡CPCy2 (3). Combination of 4 and Pd(OAc) 2 (1:1) gave an active catalyst for the palladium-catalyzed Suzuki coupling of aryl bromides with phenylboronic acid; the catalytic reactions can be performed even under low catalyst loadings (0.1-0.001 mol% 4/Pd(OAc) 2). Compound 4 has been proved to be an authentic and effective mono-dentate phosphine ligand. Crucial factors such as 4/Pd(OAc)2 ratio, base being used, solvent volume, temperature, and electronic variation of the aryl bromides in reactions were also investigated and results are reported.
