849777-20-4

Basic information

• Product Name: 3-Pyridinecarboxamide, 4-[[2-(5-chloro-2-fluorophenyl)-4-pteridinyl]amino]-, monohydrochloride
• CAS NO: 849777-20-4
• Molecular Formula: C18H11ClFN7O.ClH
• Molecular Weight: 432.244
• Mol File: 849777-20-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-Pyridinecarboxamide, 4-[[2-(5-chloro-2-fluorophenyl)-4-pteridinyl]amino]-, monohydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinecarboxamide, 4-[[2-(5-chloro-2-fluorophenyl)-4-pteridinyl]amino]-, monohydrochloride(849777-20-4)
• EPA Substance Registry System: 3-Pyridinecarboxamide, 4-[[2-(5-chloro-2-fluorophenyl)-4-pteridinyl]amino]-, monohydrochloride(849777-20-4)

Safety Data

• Hazardous Substances Data: 849777-20-4(Hazardous Substances Data)

Upstream product

• 171178-34-0 4-(tert-butoxycarbonylamino)pyridine-3-carboxylic acid 
• 280115-84-6 4-tert-butoxycarbonylamino-nicotinic acid methyl ester 
• 1015236-21-1 4-chloro-2-(5-chloro-2-fluoro-phenyl)-pteridine 
• 849777-18-0 4-amino nicotinamide trifluoroacetate salt 

Relevant articles and documents

QUINAZOLINE DERIVATIVES AS MEDICAMENTS

Quinazoline derivatives have the formula (I) or the pharmaceutically acceptable salts thereof; wherein each of Z5, Z6, Z7 and Z8 is N or CH and wherein one or two Z5, Z6, Z7 and Z8 are N and wherein two adjacent Z positions cannot be N; wherein m and n are each independently 0-3; wherein R1 is independently OH, SH, NH2, OR, SR, NHR, halo or R-halide; wherein two adjacent R1 groups may be joined to form an aliphatic hetero cycle ring of 5-6 members; wherein R2 is independently R, halo, R-halide, OR-halide, NH2, CONH2 or CONHR; wherein R is optionally substituted C1-C12 alkyl, C1-C12 alkenyl, C1-C12 alkynyl, or aryl C1-C12 alkyl, containing 0-4 heteroatoms in place of a carbon in the carbon backbone, where the optional substituents are =O, =N, or OH; and wherein R3 is H or CH3. Such compounds are useful in pharmaceutical compositions and methods of treating conditions characterized by enhanced TGFβ activity.