849797-52-0

Upstream product

• 209860-36-6 10-hydroxy-deca-5,8-diynoic acid methyl ester 
• 785822-74-4 (5Z,8Z)-10-Hydroxy-deca-5,8-dienoic acid methyl ester 
• 785822-64-2 (5Z,8Z)-10-Bromo-deca-5,8-dienoic acid methyl ester 
• 897365-00-3 (5Z,8Z,12E)-(R)-11-tert-Butoxycarbonyloxy-13-((4R,5S)-2-methoxy-5-pentyl-[1,3]dioxolan-4-yl)-trideca-5,8,12-trienoic acid methyl ester 
• 897365-04-7 methyl 11(R)-hydroxy-12-oxo-15(S)-(t-butyldimethylsiloxy)eicosa-5(Z),8(Z),13(E)-trienoate 
• 897365-01-4 (5Z,8Z)-10-[(4R,5R)-5-((E)-(S)-3-Formyloxy-oct-1-enyl)-2-oxo-[1,3]dioxolan-4-yl]-deca-5,8-dienoic acid methyl ester 
• 897365-02-5 (5Z,8Z)-10-[(4R,5S)-5-((E)-(S)-3-Formyloxy-oct-1-enyl)-2-oxo-[1,3]dioxolan-4-yl]-deca-5,8-dienoic acid methyl ester 
• 897364-98-6 (5Z,8Z,12E)-(R)-11-Hydroxy-13-((4R,5S)-2-methoxy-5-pentyl-[1,3]dioxolan-4-yl)-trideca-5,8,12-trienoic acid methyl ester 
• 897365-08-1 (5Z,8Z)-10-[(4R,5R)-5-((E)-(S)-3-Hydroxy-oct-1-enyl)-2-oxo-[1,3]dioxolan-4-yl]-deca-5,8-dienoic acid methyl ester 
• 89410-75-3 methyl 11(R),14(R),15(S)-trihydroxyeicosa-5(Z),8(Z),12(E)-trienoate 
• 785822-72-2 methyl 11(R),12(S),15(S)-trihydroxyeicosa-5(Z),8(Z),13(E)-trienoate 
• 897365-09-2 (5Z,8Z)-10-{(4R,5R)-5-[(E)-(S)-3-(tert-Butyl-dimethyl-silanyloxy)-oct-1-enyl]-2-oxo-[1,3]dioxolan-4-yl}-deca-5,8-dienoic acid methyl ester 
• 897365-03-6 methyl 11(R),12(R)-dihydroxy-15(S)-(t-butyldimethylsiloxy)eicosa-5(Z),8(Z),13(E)-trienoate 

Relevant academic research and scientific papers

Allylic alcohol transposition by ortho ester-initiated carbonate extension. Synthesis of the vasodilator 11(R),12(S),15(S)-trihydroxyeicosa-5(Z),8(Z),13(E) -trienoic acid

The title compound 1 was obtained via methyl ester 2, which was synthesized in four steps from an isomeric 11,14,15-triol ester 5. In the key step, Boc orthoformate 9 was treated with TMS triflate to initiate intramolecular nucleophilic substitution with

Asymmetric synthesis of the stereoisomers of 11,12,15(S)-trihydroxyeicosa- 5(Z),8(Z),13(E)-trienoic acid, a potent endothelium-derived vasodilator

The four stereoisomers 11,12,15(S)-THETA were prepared by a triply convergent, asymmetric route that exploited the stereospecific, copper mediated cross-coupling of α,β-dialkoxystannanes and the utility of dialkylthionocarbamates as orthogonal alcohol pro