849802-05-7

Basic information

• Product Name: 1H-Pyrrolo[3,2-c]pyridine-2-carboxaldehyde, 4,5,6,7-tetrahydro-5-(phenylmethyl)-
• CAS NO: 849802-05-7
• Molecular Formula: C15H16N2O
• Molecular Weight: 240.305
• Mol File: 849802-05-7.mol

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrolo[3,2-c]pyridine-2-carboxaldehyde, 4,5,6,7-tetrahydro-5-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrolo[3,2-c]pyridine-2-carboxaldehyde, 4,5,6,7-tetrahydro-5-(phenylmethyl)-(849802-05-7)
• EPA Substance Registry System: 1H-Pyrrolo[3,2-c]pyridine-2-carboxaldehyde, 4,5,6,7-tetrahydro-5-(phenylmethyl)-(849802-05-7)

Safety Data

• Hazardous Substances Data: 849802-05-7(Hazardous Substances Data)

Upstream product

• 3612-20-2 1-phenylmethyl-4-piperidone 
• 68-12-2 N,N-dimethyl-formamide 
• 272442-27-0 5-benzyl-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridine 
• 949-69-9 N-benzyl-4-(N-hydroxyimino)piperidine 

Downstream Products

• 1446219-98-2 C₂₆H₂₇N₃O₂ 

Relevant articles and documents

Discovery of novel indolinone-based, potent, selective and brain penetrant inhibitors of LRRK2

Mutations in leucine-rich repeat kinase-2 (LRRK2) are the most common genetic cause of Parkinson's disease (PD). The most frequent kinase-enhancing mutation is the G2019S residing in the kinase activation domain. This opens up a promising therapeutic avenue for drug discovery targeting the kinase activity of LRRK2 in PD. Several LRRK2 inhibitors have been reported to date. Here, we report a selective, brain penetrant LRRK2 inhibitor and demonstrate by a competition pulldown assay in vivo target engagement in mice.