849811-78-5

Basic information

• Product Name: Pitavastatin Methyl Ester
• Synonyms: Pitavastatin Methyl Ester;(3R,5S,E)-Methyl 7-(2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl)-3,5-dihydroxyhept-6-enoate;Methyl (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoate;DOLM;(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid methyl ester;sodium,(3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoate
• CAS NO: 849811-78-5
• Molecular Formula: C₂₆H₂₆FNO₄
• Molecular Weight: 435.4873432
• Mol File: 849811-78-5.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Pitavastatin Methyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: Pitavastatin Methyl Ester(849811-78-5)
• EPA Substance Registry System: Pitavastatin Methyl Ester(849811-78-5)

Safety Data

• Hazardous Substances Data: 849811-78-5(Hazardous Substances Data)

Usage

Uses

Pitavastatin Methyl Ester is the methyl ester derivative of Pitavastatin (P531000, Ca Salt); a competitive inhibitor of HMG-CoA reductase and an antilipemic agent.

Upstream product

• 121660-11-5 2-cyclopropyl-4-(4-fluorophenyl)-3-(hydroxymethyl)quinoline 
• 121660-37-5 2-cyclopropyl-4-(4-fluorophenyl)-3-formylquinoline 
• 765-43-5 Cyclopropyl methyl ketone 
• 164576-45-8 (4R-cis)-6-formyl-2,2-dimethyl-1,3-dioxane-4-acetic acid methyl ester 
• 140164-51-8 methyl 2-((4R,6S)-6-(hydroxymethyl)-2,2-dimethyl-1,3-dioxane-4-yl)acetate 
• 352-34-1 4-fluoro-1-iodobenzene 

Downstream Products

• 147526-32-7 pitavastatin calcium salt 
• 147526-32-7 pitavastatin 
• 1213706-08-1 (3R,5S,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoic acid (R)-NEA salt 

Relevant articles and documents

Substrate stereocontrol in bromine-induced intermolecular cyclization: Asymmetric synthesis of pitavastatin calcium

A novel approach to synthesize pitavastatin calcium (1), an effective HMG-CoA reductase inhibitor, based on readily available and attractively functionalized (R)-3-chloro-1,2-propanediol is reported. This work highlights an intermolecular diastereoselective bromine-induced cyclization of homoallylic carbonate to meet stereochemical challenges in the synthesis of statins. An efficient route to a new triphenylphosphonium tetrafluoroborate salt of a quinoline core is also presented.

PROCESS FOR PREPARING STATINS

Process for the preparation of β-ketoester synthetic intermediates useful in the preparation of statins, in particular Pitavastatin.