84994-31-0Relevant academic research and scientific papers
Synthesis of Fused Heterocycles Based on 1-Amino-1H-tetrazole-5-thiol and α,β-Unsaturated Aldehydes
Gurenkova, Yu. S.,Khramchikhin, A. V.,Kornyakov, I. V.,Ostrovsky, V. A.,Skrylnikova, M. A.
, p. 1202 - 1206 (2020)
Abstract: 8-Phenyltetrazolo[5,1-b][1,3,4]thiadiazepine was obtained as a result of intermolecular cyclization of 1-amino-1H-tetrazole-5-thiol and 3-phenyl-2-propynal. The reaction of α-bromocinnamaldehyde with 1-amino-1H-tetrazole-5-thiol led to the formation of 7-benzylidene-7H-tetrazolo[5,1-b][1,3,4]thiadiazine. An effective method was developed for the synthesis of 1-[(3-phenylprop-2-yn-1-yl)amino]-1H-tetrazole-5-thiol, a key intermediate in the possible synthesis of 7-benzylidene-6,7-dihydro-5H-tetrazolo[5,1-b][1,3,4]thiadiazine.
Pyrimido[5,4-e]tetrazolo[5,1-b][1,3,4]thiadiazines as a new heterocyclic system
Eshghi, Hossein,Rahimizadeh, Mohammad,Saberi, Sattar,Abnous, Khalil,Bakavoli, Mehdi
, p. 553 - 555 (2013)
Six novel 2-substituted pyrimido[5,4-e]tetrazolo[5,1-b][1,3,4]thiadiazines were prepared via a multistep synthetic sequence beginning with 5-bromo-2,4-dichloro-6-methylpyrimidine. Website
Facile synthesis of some novel 6-alkyl or aryl-7H-tetrazolo[5,1-b][1,3,4] thiadiazine
Eftekhar, Melika,Eshghi, Hossein,Rahimizadeh, Mohammad,Bakavoli, Mehdi,Saberi, Sattar
, p. 365 - 367 (2014/07/08)
New bis-heterocyclic thiadiazine derivatives containing a tetrazole nucleus have been synthesised by simple, high yielding routes and characterised by FT-IR, 1H NMR, 13C NMR and mass spectral analysis. The key step in the construction of the sixsubstituted 7H-tetrazolo[5,1-b][1,3,4]thiadiazine derivatives involved the cyclocondensation of sodium 1-amino-1H-tetrazole-5- thiolate with a-haloketones. The radical scavenging activity of the new tetrazolothiadiazines was also investigated.
Cephalosporin derivatives and bactericides containing the same
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, (2008/06/13)
Cephalosporin compounds represented by the following formula (I) and pharmaceutically acceptable salts thereof have a broad bactericidal spectrum against various pathogenic bacteria including Psuedomonas aeruginosa and are useful as bactericidal remedies for pathogenic diseases of human and animals: STR1 wherein A represents an unsubstituted or substituted pyridylthio group of a formula (I-1); STR2 or an unsubstituted or substituted pyridiniumthio group of a formula (I-2): STR3 or an unsubstituted or substituted pyridinium group of a formula (I-3); STR4 or a 5- or 6-membered heterocyclicthio or bicycloheterocyclicthio group of a formula (I-4):
Cephalosporin compound and process for preparing the same
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, (2008/06/13)
A cephalosporin compound of the formula: STR1 wherein R1 is a hydrogen atom, a lower alkyl group, a carboxy(lower)alkyl group, a hydroxy(lower)alkyl group, a carbamoyl(lower)alkyl group, an N-(lower)alkyl-carbamoyl(lower)alkyl group, a cycloalkyl group, a carboxycycloalkyl group, or a tetrazolylmethyl group, R2 is a hydrogen atom, a lower alkyl group, a formyl group or a lower alkanol group, R3 is a hydrogen atom, or R2 and R3 are combined together to form an aralkylidene group, or a pharmaceutically acceptable salt thereof which is useful as an antimicrobial agent, and process for their preparation.
Pyrrolidomoxine cephalosporins
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, (2008/06/13)
A 7β-{(Z)-2-(2-aminothiazol-4-yl)-2-[(2-pyrrolidon-3-yl)oxyimino]acetamido}-3-(1-amino-1H-tetrazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid or a pharmaceutically acceptable salt thereof is useful as an antimicrobial agent.
