84995-56-2Relevant academic research and scientific papers
Buchwald-Hartwig amination of (hetero)aryl chlorides by employing Mor-DalPhos under aqueous and solvent-free conditions
Tardiff, Bennett J.,Stradiotto, Mark
, p. 3972 - 3977 (2012)
We report on the application of the [Pd(cinnamyl)Cl]2/Mor- DalPhos catalyst system in the Buchwald-Hartwig amination of (hetero)aryl chlorides with primary or secondary amines conducted either under aqueous conditions without the use of co-solvents and/or surfactants or under solvent-free conditions (52 examples). We have established that reactions of this type can be conducted without the rigorous exclusion of air, and in the case of the solvent-free reactions, we have demonstrated that appropriately selected liquid and solid reagents can be employed successfully.
