850010-55-8

Basic information

• Product Name: ethyl 3,6-dimethyl-2-phenyl-4-quinolinecarboxylate
• Synonyms: ethyl 3,6-dimethyl-2-phenyl-4-quinolinecarboxylate
• CAS NO: 850010-55-8
• Molecular Formula: C₂₀H₁₉NO₂
• Molecular Weight: 305.37036
• Mol File: 850010-55-8.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl 3,6-dimethyl-2-phenyl-4-quinolinecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3,6-dimethyl-2-phenyl-4-quinolinecarboxylate(850010-55-8)
• EPA Substance Registry System: ethyl 3,6-dimethyl-2-phenyl-4-quinolinecarboxylate(850010-55-8)

Safety Data

• Hazardous Substances Data: 850010-55-8(Hazardous Substances Data)

Upstream product

• 436089-38-2 3,6-dimethyl-2-phenylquinoline-4-carboxylic acid 
• 64-17-5 ethanol 

Downstream Products

• 850010-59-2 3,6-bis-bromomethyl-2-phenylquinoline-4-carboxylic acid ethyl ester 

Relevant articles and documents

Synthesis of brequinar analogue inhibitors of malaria parasite dihydroorotate dehydrogenase

A series of 2-phenyl quinoline-4-carboxylic acid derivatives related to brequinar, an inhibitor of human dihydroorotate dehydrogenase (DHODH), has been prepared and evaluated as inhibitors of DHODH from the malaria parasite Plasmodium falciparum. Brequinar was essentially inactive against PfDHODH (IC50 880 μM) whereas several members of the series inhibited PfDHODH. Unexpectedly, replacement of the carboxylic acid required for brequinar to inhibit hDHODH was not essential in the diisopropylamides that inhibited PfDHODH.