850021-27-1Relevant articles and documents
NOVEL COMPOUNDS FOR THE TREATMENT, ALLEVIATION OR PREVENTION OF DISORDERS ASSOCIATED WITH TAU AGGREGATES
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Page/Page column 41; 42, (2019/12/28)
The present invention relates to novel compounds that can be employed in the treatment, alleviation or prevention of a group of disorders and abnormalities associated with Tau (Tubulin associated unit) protein aggregates including, but not limited to, Neu
Triazolbenzo[d]thiazoles: Efficient synthesis and biological evaluation as neuroprotective agents
Avila, Belem,Roth, Aaron,Streets, Heather,Kurth, Mark J.,Dwyer, Donard S.
supporting information, p. 5976 - 5978,3 (2020/08/31)
A number of (1H-1,2,3-triazol-1-yl)benzo[d]thiazoles were synthesized utilizing a versatile Cu-catalyzed azide-alkyne click reaction (CuAAC) on tautomeric benzo[4,5]thiazolo[3,2-d]tetrazole (1) and 2-azidobenzo[d]thiazole (2) starting materials. Moreover, one of the resulting products of this investigation, triazolbenzo[d]thiazole 22, was found to possess significant neuroprotective activity in human neuroblastoma (SH-SY5Y) cells.