85003-78-7Relevant articles and documents
Synthesis and antifungal activities of 5-(o-hydroxy phenyl)-2-[4'aryl-3' chloro-2'azetidinon-1-yl]-1,3,4-thiadiazole
Gupta, Shiv K.,Sharma,Bansal,Kumar
, p. 594 - 597 (2011)
New series of 5-(o-hydroxy phenyl)-2-[4'aryl-3'chloro-2'azetidinon- 1-yl]-1,3,4-thiadiazole have been synthesized and the structures of the new compounds were established on the basis of IR, 1H NMR spectral data. In vitro antifungal activity (MIC activity) was evaluated and compared with standard drugs of ketoconazole. Compounds 3c in the series has shown interesting antifungal activity against both C. albicans and A. niger fungus. In the gratifying result, most of the compounds were found to have moderate antifungal activity.
Synthesis, characterization and biological activity study of some new metal complexes with schiff's bases derived from [o-vanillin] with [2-amino-5-(2-hydroxy-phenyl)-1,3,4-thiadiazole]
Shaalan, Naser,Mahdi, Shatha
, p. 4059 - 4067 (2021/07/31)
This study involves the preparation of a new series of dinuclear complexes Cr(III), Co(II), Ni(II), Cu(II) and Zn(II) complexes of the Schiff base (H2L) derived from Vanillin with 2amino-5-(2-hydroxy-phenyl)-1,3,4-thiadiazole has been synthesized tetradentate Schiff base ligands were used for complexation upon two metal ions of Cr(III),Co(II), Ni(II), Cu(II) and Zn(II) as dineucler formula M2L2.4H2O and M2L2. These ligands can be characterization IR ,UV-Vis , Mass, 1H-NMR and elemental microanalysis. The Synthesized complexes were characterized by IR, spectroscopy ,elemental microanalysis, electronic spectra, magnetic susceptibility conductive ,thermal Analysis (TGA) and atomic absorption on the basis of analytical data, the stoichiometry of metal to ligand in complexes and Schiff bases ligand. The Structures of complexes were proposed from the measurements. The bioactivity of the prepared complexes has been examined with antibacterial activity. Antimicrobial activities of the Schiff base ligand and their metal complexes reveal that the Schiff base transition metal complexes show significant activity against some fungi and bacteria.
Synthesis, in vitro and in silico Anti-Proliferative Studies of Novel Piperiene-Oxadiazole and Thiadiazole Analogs
Amperayani,Parimi
, p. 2301 - 2307 (2020/01/08)
Piperine is a component of pepper which has earlier been reported as anticancer active compound. This work is emphasized on the design and synthesis of new hybrid piperine analogs by coupling piperine with the amine group of oxadiazoles and thiadiazoles.