850080-01-2

Upstream product

• 83351-75-1 tert-butyl (S)-(1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)carbamate 
• 106-96-7 propargyl bromide 
• 7681-38-1 sodium hydrogen sulfate 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 850079-71-9 trifluoroacetate salt of (2S)-2-amino-3-(4-(prop-2-ynyloxy)phenyl)propionamide 

Relevant academic research and scientific papers

C-Terminal Attachment of Two Chemical Groups to Peptides

The present invention relates to a method for C-terminal attachment of two property-modifying groups to a peptide.

C-Terminally Pegylated Growth Hormones

Conjugated growth hormones of the structure (I) are provided together with methods for manufacturing said conjugates. The conjugates are useful in therapy.

COUPLING OF POLYPEPTIDES AT THE C-TERMINUS

The present invention relates to novel polypeptides, methods for their synthesis, pharmaceutical compositions comprising the novel polypeptides as well as their use in medicaments for therapeutic applications.

C-TERMINALLY PEGYLATED GROWTH HORMONES

7150.204-WO 141 ABSTRACT Conjugated growth hormones of the structure O NH2 GH Leu N H G PEG [I] are provided together with methods for manufacturing said conjugates. The conjugates are 5 useful in therapy.