85012-72-2Relevant articles and documents
Mass Spectrometry of Imidazole-4(5)-carboxaldehyde and Some 1-Methyl and Nitro Derivatives
Cert, Arturo,Delgado-Cobos, Pedro,Perez-Lanzac, Mariana Trujillo
, p. 499 - 506 (2007/10/02)
The mass spectra of imidazole-4(5)-carboxaldehyde, its two 1-methyl derivatives, 4(5)-nitroimidazole, 5(4)-nitroimidazole-4(5)-carboxaldehyde and 1-methyl-5-nitroimidazole-4-carboxaldehyde are presented and discussed in comparison with those of other imidazole-carboxaldehydes and nitroimidazoles earlier reported.The imidazole-carboxaldehydes and their 1-methyl derivatives exhibit the characteristic fragmentation of aromatic aldehydes, and differences between the isomers can be observed.The nitroimidazoles show the fragmentation typical of aromatic nitrocompounds.In the o-nitroimidazole-carboxaldehydes, the typical losses of aldehydes do not occur, but primary ortho effects between the formyl and nitro groups give rise to important fragmentation routes.In their 1-methyl derivatives, the presence of the methyl group adjacent to the nitro group originates additional double and secondary ortho effects.For some of these transformations, fragmentation mechanisms are proposed.
4,5-DISUBSTITUTED IMIDAZOLES. PART I. 4-HYDROXYMETHYL-5-NITROIMIDAZOLE, 4-FORMYL-5-NITROIMIDAZOLE AND THEIR N-SUBSTITUTED DERIVATIVES
Bochwic, Boleslaw,Frankowski, Andrzej,Kuswik, Gabriela,Seliga, Czeslawa
, p. 1055 - 1061 (2007/10/02)
A synthesis of 4-hydroxymethyl-5-nitroimidazole, 4-formyl-5-nitroimidazole, their N-methyl and N-trityl derivatives were developed starting from easily accessible 4-hydroxymethylimidazole.The structures of N-substituted derivatives have been assumed on the basis of analyzing the 1H NMR data.
