850132-07-9Relevant academic research and scientific papers
BIS-AMINES, COMPOSITIONS, AND USES RELATED TO CXCR4 INHIBITION
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Page/Page column 68; 69, (2017/02/09)
This disclosure relates bis-amine compounds disclosed herein and uses related to CXCR4 inhibition. In certain embodiments, the compounds have formula (I), salts, derivatives, and prodrugs thereof wherein, A is a bridging aryl or heterocyclyl and R1 and R2 are further disclosed herein. In certain embodiments, the disclosure contemplates pharmaceutical compositions comprising compounds disclosed herein. In certain embodiments, the disclosure relates to methods of treating or preventing CXCR4 related diseases or conditions by administering an effective amount of a compound disclosed herein to a subject in need thereof.
Symmetrical bis-tertiary amines as novel CXCR4 inhibitors
Bai, Renren,Liang, Zhongxing,Yoon, Younghyoun,Liu, Shuangping,Gaines, Theresa,Oum, Yoonhyeun,Shi, Qi,Mooring, Suazette Reid,Shim, Hyunsuk
, p. 340 - 350 (2016/05/24)
CXCR4 inhibitors are promising agents for the treatment of cancer metastasis and inflammation. A series of novel tertiary amine derivatives targeting CXCR4 were designed, synthesized, and evaluated. The central benzene ring linker and side chains were mod
Synthesis of iron(II), manganese(II), cobalt(II) and ruthenium(II) complexes containing tridentate nitrogen ligands and their application in the catalytic oxidation of alkanes
Britovsek, George J. P.,England, Jason,Spitzmesser, Stefan K.,White, Andrew J.P.,Williams, David J.
, p. 945 - 955 (2007/10/03)
A series of Fe(II), Mn(II), Co(II) and Ru(II) complexes containing bis(imino) pyridine or bis(amino)pyridine ligands and weakly coordinating triflate (OTf-) or non-coordinating SbF6- anions have been prepared. The complexes have been fully characterized including several solid-state structure analyses. Two unusual mono-chelate six-coordinate bis(imino)pyridine Fe(II) and Mn(II) complexes have been observed. The catalytic properties of the complexes for the oxidation of cyclohexane with H2O2 have been evaluated. Only the Fe(II) complexes have shown catalytic activity, which is mainly due to Fenton-type free radical auto-oxidation. The Royal Society of Chemistry 2005.
