850146-95-1

Upstream product

• 111966-93-9 (ethynyldimethylsilyl)methylbenzene 
• 490021-10-8 (3R)-(E)-1-iodohexa-1,5-dien-3-ol 
• 490020-99-0 Triethyl-[(R)-1-((E)-2-iodo-vinyl)-but-3-enyloxy]-silane 
• 1833-31-4 benzyl(chloro)dimethylsilane 
• 850146-93-9 Acrylic acid (E)-(1R,4R,5R,7R)-1-allyl-9-(benzyl-dimethyl-silanyl)-7-(tert-butyl-dimethyl-silanyloxy)-5-(3,4-dimethoxy-benzyloxymethoxy)-4-methyl-4-triethylsilanyloxy-non-2-en-8-ynyl ester 
• 850146-92-8 (E)-(3R,5R,6R,9R)-1-(Benzyl-dimethyl-silanyl)-3-(tert-butyl-dimethyl-silanyloxy)-5-(3,4-dimethoxy-benzyloxymethoxy)-6-methyl-9-triethylsilanyloxy-dodeca-7,11-dien-1-yn-6-ol 
• 850146-98-4 Acrylic acid (E)-(1R,4R,5R,7R)-1-allyl-9-(benzyl-dimethyl-silanyl)-7-(tert-butyl-dimethyl-silanyloxy)-5-(3,4-dimethoxy-benzyloxymethoxy)-4-hydroxy-4-methyl-non-2-en-8-ynyl ester 
• 850146-97-3 (E)-(4R,7R,8R,10R)-12-(Benzyl-dimethyl-silanyl)-10-(tert-butyl-dimethyl-silanyloxy)-8-(3,4-dimethoxy-benzyloxymethoxy)-7-methyl-dodeca-1,5-dien-11-yne-4,7-diol 
• 850146-91-7 (3R,5R)-7-(Benzyl-dimethyl-silanyl)-5-(tert-butyl-dimethyl-silanyloxy)-3-(3,4-dimethoxy-benzyloxymethoxy)-hept-6-yn-2-one 
• 850146-90-6 (3R,5R)-7-(Benzyl-dimethyl-silanyl)-5-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-hept-6-yn-2-one 
• 850146-89-3 (3R,5R)-1-(Benzyl-dimethyl-silanyl)-6,6-diethoxy-hept-1-yne-3,5-diol 
• 850146-88-2 (R)-1-(Benzyl-dimethyl-silanyl)-6,6-diethoxy-5-hydroxy-hept-1-yn-3-one 
• 850146-87-1 4-(benzyldimethylsilyl)but-3-yn-2-one 
• 850146-94-0 (R)-6-[(E)-(3R,4R,6R)-8-(Benzyl-dimethyl-silanyl)-6-(tert-butyl-dimethyl-silanyloxy)-4-(3,4-dimethoxy-benzyloxymethoxy)-3-methyl-3-triethylsilanyloxy-oct-1-en-7-ynyl]-5,6-dihydro-pyran-2-one 

Downstream Products

• 90730-71-5 dephosphofostriecin B 
• 850146-96-2 (R)-6-[(1E,7Z)-(3R,4R,6R)-8-(Benzyl-dimethyl-silanyl)-6-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-3-methyl-3-triethylsilanyloxy-octa-1,7-dienyl]-5,6-dihydro-pyran-2-one 

Relevant academic research and scientific papers

Synthesis of Dehydro-Dephospho-Fostriecin and Formal Total Synthesis of Fostriecin

A formal synthesis of fostriecin (1) and a total synthesis of its related congener dihydro-dephospho-fostriecin 2 have been achieved. The route relies upon the use of the Sharpless dihydroxylation to set the absolute stereochemistry at C-8/9 and Noyori tr

Dinuclear asymmetric Zn aldol additions: Formal asymmetric synthesis of fostriecin

Direct asymmetric aldol reactions constitute a powerful methodology for the efficient synthesis of complex natural products. Herein we report the first application of our recently reported dinuclear Zn-catalyzed direct aldol addition of alkynyl ketones to