850177-03-6

Basic information

• Product Name: 2-Propenoic acid, 3-[3,4-bis(methoxymethoxy)phenyl]-, ethyl ester, (2E)-
• CAS NO: 850177-03-6
• Molecular Formula: C15H20O6
• Molecular Weight: 296.32
• Mol File: 850177-03-6.mol

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 3-[3,4-bis(methoxymethoxy)phenyl]-, ethyl ester, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 3-[3,4-bis(methoxymethoxy)phenyl]-, ethyl ester, (2E)-(850177-03-6)
• EPA Substance Registry System: 2-Propenoic acid, 3-[3,4-bis(methoxymethoxy)phenyl]-, ethyl ester, (2E)-(850177-03-6)

Safety Data

• Hazardous Substances Data: 850177-03-6(Hazardous Substances Data)

Upstream product

• 139-85-5 3,4-dihydroxybenzaldehyde 
• 6515-06-6 3,4-bis-methoxymethoxy-benzaldehyde 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 

Downstream Products

• 115610-32-7 (2E)-cinnamyl 3-(3,4-dihydroxyphenyl)acrylate 
• 850176-72-6 3-(4-methoxymethoxyphenyl)propenyl 3-(3,4-dimethoxymethoxyphenyl)allylate 
• 850176-70-4 3-(3,4-bis-methoxymethoxy-phenyl)-acrylic acid 3-phenyl-allyl ester 
• 850177-05-8 (E)-3-[3,4-bis(methoxymethoxy)phenyl]acrylic acid 

Relevant articles and documents

Synthesis and biological evaluation of a natural ester sintenin and its synthetic analogues

Synthesis of 3-(3,4-dimethoxyphenyl)propyl-3-(3,4-dimethoxyphenyl) propanoate (18), a cytotoxic natural ester, was carried out by a convenient synthetic path with a total yield of 49%. Sixteen of its analogues (19-34) were also prepared. Seventeen unsaturated derivatives of 18, compounds 1-17, were also synthesized to examine the structure-activity relationship of this type of ester. All of the synthetic compounds were passed through the cytotoxicity screenings on human tumor cell lines, such as PC-3, Hela, A549, BEL7404, CNE, and KB. Some of the esters exhibited moderate inhibitory effects on these tumor cell lines. The phenolic derivatives exhibited the highest cytotoxicity among these derivatives, while the unsaturated esters were more cytotoxic than the saturated analogues. Some of the compounds also exhibited inhibition on α-glucosidase.