850232-16-5

Upstream product

• 1283671-38-4 2-(4-benzyloxyphenyl)ethyl β-D-galactopyranoside 
• 1283670-85-8 C₂₂H₂₈O₁₁ 
• 501-94-0 p-hydroxyphenethyl alcohol 
• 60037-43-6 2-(4-acetoxyphenyl)ethanol 

Relevant academic research and scientific papers

Development of a kilogram-scale synthesis of salidroside and its analogs

An efficient, safe, and viable process has been developed for large-scale preparation of salidroside, a natural product. The process consists of two chemical steps, which produce the salidroside on a multikilogram scale with 72% overall yield and >98% purity.A series of novel salidroside analogs were prepared according to the same method. Taylor & Francis Group, LLC.

Synthesis, biological activity of salidroside and its analogues

Salidroside is a phenylpropanoid glycoside isolated from Rhodiola rosea L., a traditional Chinese medicinal plant, and has displayed a broad spectrum of pharmacological properties. In this paper, about 18 novel salidroside analogues were prepared through Koenigs-Knorr method, the effects of these compounds over PC12 was assessed with the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. The novel compounds differ in the substituents attached to the benzene ring or in the glycosyl donor. According to the data, compounds (3,5-dimethoxyphenyl)methyl β-D-glucopyranoside and (3,5-dimethoxyphenyl) methyl β-D-galactopyranoside with methoxy group at 3 and 5-positions of the benzene ring were the most viability at concentration of 300 μmol/l and 60 μmol/l, respectively.