850307-91-4

Upstream product

• 59434-20-7 1,3,5-tri-O-benzylphloroglucinol 
• 63604-98-8 1,3-dibenzylphloroglucinol 
• 155697-42-0 (E)-3-(3-(benzyloxy)phenyl)prop-2-en-1-ol 

Downstream Products

• 850307-84-5 (2S,3S)-5,7-bis(benzyloxy)-2-(3-benzyloxyphenyl)chroman-3-yl 3,4,5-tris(benzyloxy)benzoate 
• 850307-76-5 (1S,2S)-3-[2,4-bis(benzyloxy)-6-hydroxyphenyl]-1-(3-benzyloxyphenyl)propane-1,2-diol 
• 850307-77-6 (2S,3S)-cis-5,7-bis(benzyloxy)-2-(3-benzyloxyphenyl)chroman-3-ol 
• 863237-61-0 3,4,5-Tris-benzyloxy-benzoic acid (2R,3R)-5,7-bis-benzyloxy-2-(3-benzyloxy-phenyl)-chroman-3-yl ester 
• 863237-46-1 (1R,2R)-1-(3'-benzyloxyphenyl)-3-(2''-hydroxy-4'',6''-dibenzyloxyphenyl)propane-1,2-diol 
• 863237-47-2 Formic acid (1R,2S)-2-(3-benzyloxy-phenyl)-1-(2,4-bis-benzyloxy-6-hydroxy-benzyl)-2-bromo-ethyl ester 
• 863237-48-3 (2R,3R)-2-(3-benzyloxy-phenyl)-5,7-dibenzyloxy-chroman-3-ol 

Relevant academic research and scientific papers

PROCESSES FOR THE PREPARATION OF ORTHO-ALLYLATED HYDROXY ARYL COMPOUNDS

The present application describes process for preparing an ortho-allylated hydroxy aryl compounds such as compounds of Formula (I) by reacting an allylic alcohol with a hydroxy aryl compound in the presence of aluminum compound selected from alumina and aluminum alkoxides and in a non-protic solvent wherein at least one carbon atom ortho to the hydroxy group in the hydroxy aryl compound is unsubstituted. The present application also includes compounds of Formula (I).

Structure-activity study of epi-gallocatechin gallate (EGCG) analogs as proteasome inhibitors

The structure-activity relationship of a number of synthetic green tea polyphenol analogs involving modifications of A ring and B ring of epi-gallocatechin gallate (EGCG) as proteasome inhibitors has been examined. It was found that in B ring, a decrease in the number of OH groups led to decreased potency. Introduction of a hydrophobic benzyl group into the 8 position of A ring did not significantly affect the proteasome-inhibitory potency.