850314-49-7

Upstream product

• 850314-47-5 2-tert-butyl-5-chloro-1,1-dioxo-1,2-dihydro-1λ⁶-isothiazol-3-one 
• 850314-48-6 Nα-(tert-butoxycarbonyl)-4-(dihydroxyboryl)-N-pentyl-L-phenylalaninamide 
• 119771-23-2 N-(tert-butoxycarbonyl)-4-(dihydroxyboryl)-1-phenylalanine 
• 110-58-7 n-Pentylamine 

Downstream Products

• 910606-99-4 3-[4-(2-tert-butyl-1,1,3-trioxo-1λ⁶-isothiazolidin-5-yl)-phenyl]-2-{2-[2-(4-methoxy-phenyl)-acetylamino]-3-phenyl-propionylamino}-N-pentyl-propionamide 
• 910606-98-3 3-[4-(2-tert-butyl-1,1,3-trioxo-1λ⁶-isothiazolidin-5-yl)-phenyl]-2-{2-[2-(4-methoxy-phenyl)-acetylamino]-3-phenyl-propionylamino}-N-pentyl-propionamide 
• 850315-77-4 (2S)-3-[4-(2-tert-butyl-1,1,3-trioxo-2,3-dihydroisothiazol-5-yl)phenyl]-2-[((2S)-2-{[(4-methoxyphenyl)acetyl]amino}-3-phenylpropanoyl)amino]-N-pentylpropanamide 
• 910606-87-0 tert-butyl ((1S)-1-benzyl-2-{[(1S)-1-[4-(2-tert-butyl-1,1,3-trioxo-2,3-dihydroisothiazol-5-yl)benzyl]-2-oxo-2-(pentylamino)ethyl]amino}-2-oxoethyl)carbamate 

Relevant academic research and scientific papers

Isothiazolidinone heterocycles as inhibitors of protein tyrosine phosphatases: Synthesis and structure-activity relationships of a peptide scaffold

The structure-based design and discovery of the isothiazolidinone (IZD) heterocycle as a mimic of phosphotyrosine (pTyr) has led to the identification of novel IZD-containing inhibitors of protein tyrosine phosphatase 1B (PTP1B). The structure-activity re