850321-49-2

Upstream product

• 850320-85-3 3-(3-bromo-4-iodo-phenyl)-2-tert-butoxycarbonylamino-propionic acid benzyl ester 
• 929617-84-5 3-(4-amino-3-bromo-phenyl)-2-tert-butoxycarbonylamino-propionic acid benzyl ester 
• 33305-77-0 Boc-Phe(p-NO₂)-OH 
• 184684-96-6 p-amino-N-tert-butyloxycarbonyl-L-phenylalanine benzyl ester 
• 127977-25-7 benzyl 2(S)-<(tert-butoxycarbonyl)amino>-3-(4'-nitrophenyl)propionate 

Downstream Products

• 850320-86-4 [1-(1H-benzoimidazol-2-yl)-2-(3-bromo-4-iodo-phenyl)-ethyl]-carbamic acid tert-butyl ester 
• 850320-89-7 2-{2-[3-bromo-4-(2-tert-butyl-1,1,3-trioxo-1λ⁶-isothiazolidin-5-yl)-phenyl]-1-tert-butoxycarbonylamino-ethyl}-benzoimidazole-1-carboxylic acid tert-butyl ester 
• 850320-88-6 2-{2-[3-bromo-4-(2-tert-butyl-1,1,3-trioxo-2,3-dihydro-1H-1λ⁶-isothiazol-5-yl)-phenyl]-1-tert-butoxycarbonylamino-ethyl}-benzoimidazole-1-carboxylic acid tert-butyl ester 
• 850321-04-9 5-{4-[2-(1H-benzoimidazol-2-yl)-2-(benzothiazol-2-ylamino)-ethyl]-2-bromo-phenyl}-1,1-dioxo-1λ⁶-isothiazolidin-3-one 
• 850320-87-5 2-[2-(3-bromo-4-iodo-phenyl)-1-tert-butoxycarbonylamino-ethyl]-benzoimidazole-1-carboxylic acid tert-butyl ester 
• 850320-90-0 5-{4-[2-amino-2-(1H-benzoimidazol-2-yl)-ethyl]-2-bromo-phenyl}-2-tert-butyl-1,1-dioxo-1λ⁶-isothiazolidin-3-one 

Relevant academic research and scientific papers

Benzothiazole benzimidazole (S)-isothiazolidinone derivatives as protein tyrosine phosphatase-1B inhibitors

Benzothiazole benzimidazole (S)-isothiazolidinone ((S)-IZD) derivatives 5 were discovered through a peptidomimetic modification of the tripeptide (S)-IZD protein tyrosine phosphatase 1B (PTP1B) inhibitor 1. These derivatives are potent, competitive, and r