850363-30-3

Basic information

• Product Name: 5-[4-(1-tert-butoxycarbonylamino-1-methylethyl)phenyl]-4-(pyrazol-4-yl)-2-(tetrahydropyran-2-yl)-2H-indazole
• Synonyms: 5-[4-(1-tert-butoxycarbonylamino-1-methylethyl)phenyl]-4-(pyrazol-4-yl)-2-(tetrahydropyran-2-yl)-2H-indazole
• CAS NO: 850363-30-3
• Molecular Weight: 501.629
• Mol File: 850363-30-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-[4-(1-tert-butoxycarbonylamino-1-methylethyl)phenyl]-4-(pyrazol-4-yl)-2-(tetrahydropyran-2-yl)-2H-indazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[4-(1-tert-butoxycarbonylamino-1-methylethyl)phenyl]-4-(pyrazol-4-yl)-2-(tetrahydropyran-2-yl)-2H-indazole(850363-30-3)
• EPA Substance Registry System: 5-[4-(1-tert-butoxycarbonylamino-1-methylethyl)phenyl]-4-(pyrazol-4-yl)-2-(tetrahydropyran-2-yl)-2H-indazole(850363-30-3)

Safety Data

• Hazardous Substances Data: 850363-30-3(Hazardous Substances Data)

Upstream product

• 552846-17-0 tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole-1-carboxylate 
• 850363-05-2 5-[4-(1-tert-Butoxycarbonylamino-1-methylethyl)-phenyl]-2-(tetrahydropyran-2-yl)-4-trifluoromethane-sulfonyloxy-2H-indazole 

Relevant articles and documents

NOVEL INDAZOLE DERIVATIVE

An object of the present invention is to create a novel indazole derivative useful as a drug and to find a novel pharmacological action of the derivative. The compound of the present invention is represented by the formula [I] and has an excellent Rho kinase inhibiting action. In the formula, a ring X is a benzene ring or a pyridine ring; R1 and R2 are H or alkyl; R3 and R4 are halogen, H, OH, alkoxy, alkenyloxy, alkynyloxy, cycloalkyloxy, cycloalkenyloxy, aryloxy, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, carboxy, hydrocarbonyl, alkylcarbonyl, etc.; and R5 is halogen atom, H, OH, alkoxy, aryloxy, alkyl or aryl. Each group can be substituted.