850363-63-2

Basic information

• Product Name: 1H-Indazole, 1-acetyl-4-methoxy- (9CI)
• Synonyms: 1H-Indazole, 1-acetyl-4-methoxy- (9CI);1-(4-Methoxy-1H-indazol-1-yl)ethanone
• CAS NO: 850363-63-2
• Molecular Formula: C10H10N2O2
• Molecular Weight: 190.2
• Mol File: 850363-63-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Indazole, 1-acetyl-4-methoxy- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indazole, 1-acetyl-4-methoxy- (9CI)(850363-63-2)
• EPA Substance Registry System: 1H-Indazole, 1-acetyl-4-methoxy- (9CI)(850363-63-2)

Safety Data

• Hazardous Substances Data: 850363-63-2(Hazardous Substances Data)

Usage

General Description

1H-Indazole, 1-acetyl-4-methoxy- (9CI) is a chemical compound belonging to the class of indazoles, which are heterocyclic compounds containing a five-membered ring fused to a benzene ring. This particular chemical is characterized by the presence of an acetyl group and a methoxy group attached to the indazole ring. It is commonly used in the field of chemistry and pharmaceutical research as a building block for the synthesis of various bioactive compounds and pharmaceutical drugs. Additionally, 1H-Indazole, 1-acetyl-4-methoxy- (9CI) may exhibit certain pharmacological properties due to its structural features, making it a potential candidate for further investigation in drug discovery and development.

Upstream product

• 108-24-7 acetic anhydride 
• 351210-06-5 4-methoxy-1H-indazole 

Relevant articles and documents

Synthesis method of 5-bromo-4-methoxy-1H-indazole

The invention belongs to the field of organic synthesis, and particularly relates to a synthetic method of 5-bromo-4-methoxy-1H-indazole. The synthesis method provided by the invention comprises the following steps: (1) dissolving 4-methoxy-1H-indazole in toluene, heating the component to 70-110 DEG C, adding acetic anhydride, and performing a reaction for 0.5 h to obtain 1-(4-methoxy-1H-indazole-1-yl) ethyl ketone; (2) dissolving 1-(4-methoxy-1H-indazole-1-yl) ethyl ketone into tetrahydrofuran, adding N-bromosuccinimide, stirring the components in an ice bath for 1 hour, and removing the icebath to react for 12 hours, so as to obtain 1-(5-bromo-4-methoxy-1H-indazole-1-yl) ethyl ketone; and (3) dissolving 1-(5-bromo-4-methoxy-1H-indazole-1-yl) ethyl ketone in methanol, then adding ammoniawater, and carrying out a stirring reaction for 1 h so as to obtain 5-bromo-4-methoxy-1H-indazole. The compound provided by the invention can be used as an important drug intermediate, and the synthesis method has the advantages of simple synthesis path, high product yield and the like.

PROTECTIVE AGENT FOR RETINAL NEURONAL CELL COMPRISING INDAZOLE DERIVATIVE AS ACTIVE INGREDIENT

As a result of intensive studies for the purpose of finding a new medicinal use of an indazole derivative, it was found that an indazole derivative inhibits glutamate-induced retinal neuronal cell death in rat fetal retinal neuronal cells, in other words, the indazole derivative acts directly on the retinal neuronal cells and exhibits an effect of protecting retinal neuronal cells. Accordingly, the indazole derivative is useful for the prevention or treatment of an eye disease associated with retinal neuronal cell damage or retinal damage.